Integrative Treatment for Achieving Holistic Recovery from Comorbid Chronic Pain and Opioid Use Disorder

项目摘要 母公司Grant，UNM IMPOWR中心(新墨西哥大学慢性病综合管理 疼痛和阿片类药物使用障碍用于整个康复；RM1DA055301；MPIS Witkiewitz，Pearson)，寻求利用 评估和治疗导致疼痛和阿片类药物使用障碍的生物、心理和社会因素的整体方法 (OUD)，并改善各种慢性疼痛和阿片类药物滥用患者的生活 社区。UNM IMPOWR有两个主要研究项目。希望试验是一种多点有效性- 慢性疼痛与尿毒症综合治疗的临床研究 (接受和承诺疗法[ACT]和基于正念的复发预防[MBRP])。这个 Options Trial使用基于社区的参与式研究(CBPR)方法来开发以文化为中心的 美国印第安人/阿拉斯加土著人初级保健诊所对慢性疼痛和OUD的干预 美国励志访谈。UNM IMPOWR还召集了一个社区咨询委员会，并 科学顾问委员会，帮助指导计划的制定、实施和最大限度地开展研究 冲击力。多样性副刊的研究目的是：1)启动以文化为中心的进程 慢性疼痛和阿片类药物使用障碍的综合治疗(接受和承诺治疗和 基于正念的复发预防)在美国的西班牙裔/拉丁裔/a/x个人；2)检查 对疼痛、认知的生态瞬时评估研究的可接受性、可行性和依从性比率 输血、渴望、正念和承受痛苦；以及3)评估内部和之间的程度- 感兴趣结构的主体变异性，包括疼痛、认知融合、渴望、正念和苦恼 宽容。增刊的培训目标是：1)获得以社区为基础的参与式培训 研究；2)获得阿片类药物使用障碍的心理社会治疗方面的培训；3)获得 针对纵向和密集纵向数据的高级量化方法；4)接受培训 定性研究方法和定性数据分析；5)接受手稿制作培训， 研究传播(例如，海报、座谈会)，撰写NIH拨款申请，以及负责任的行为 研究的成果。最终，整体的培训和研究经验将为Schwebel博士成为一名 成功的独立研究人员检查慢性疼痛和OUD。

Project Summary The Parent Grant, the UNM IMPOWR Center (University of New Mexico Integrative Management of chronic Pain and Opioid use disorder for Whole Recovery; RM1DA055301; mPIs Witkiewitz, Pearson), seeks to utilize a holistic approach to assess and treat biopsychosocial factors that contribute to pain and opioid use disorder (OUD), and improve the lives of diverse individuals with chronic pain and opioid misuse/OUD in diverse communities. UNM IMPOWR has two major research projects. The HOPE Trial is a multisite effectiveness- implementation trial investigating the effectiveness of an integrated treatment for chronic pain and OUD (Acceptance and Commitment Therapy [ACT] and Mindfulness-Based Relapse Prevention [MBRP]). The OPTIC Trial uses community-based participatory research (CBPR) methods to develop a culturally centered intervention for chronic pain and OUD in American Indian/Alaska Native primary care clinics based on Native American Motivational Interviewing. UNM IMPOWR has also convened a community advisory board and scientific advisory board to help guide program development, implementation, and to maximize research impact. The research aims of the diversity supplement are to 1) begin the process to culturally center two integrated treatments for chronic pain and opioid use disorder (Acceptance and Commitment Therapy and Mindfulness-Based Relapse Prevention) for Hispanic/Latino/a/x individuals in the United States; 2) examine acceptability, feasibility, and compliance rates of an ecological momentary assessment study of pain, cognitive defusion, craving, mindfulness, and distress tolerance ; and 3) evaluate the degree of within- and between- subject variability in constructs of interest including pain, cognitive defusion, craving, mindfulness, and distress tolerance. The training aims of the supplement are to 1) acquire training in community-based participatory research; 2) acquire training in psychosocial treatments for opioid use disorder; 3) obtain experience in advanced quantitative approaches for longitudinal and intensive longitudinal data; 4) receive training in qualitative research methods and qualitative data analysis; and 5) receive training in manuscript production, research dissemination (e.g., posters, symposia), writing NIH grant applications, and the responsible conduct of research. Ultimately, the overall training and research experiences will prepare Dr. Schwebel to become a successful independent researcher examining chronic pain and OUD.