Animal Modeling Core

项目总结/ 动物建模核心(AMC)的任务是在基督教青年会和更大范围内提供研究小组 科学界获得动物模型血液学研究的最新技术。体内研究 允许研究人员提出关于分子、细胞群体和组织在 相关的空间和时间背景。青年科学家中心将继续为科学家提供培训和便利 血液病小鼠模型的研究。重要的是，AMC将继续发展和宣传 用于研究人类造血及其疾病的最具创新性的人源化小鼠模型 目标是克服当前模式的主要缺点。AMC由两个核心组成，人性化的 小鼠核心(HMC)和小鼠干细胞移植核心(MSCTC)。动物造型的核心意志 由斯特林免疫生物学教授理查德·弗拉维尔博士执导，斯蒂芬妮·哈琳博士联合执导， 血液学副教授兼代理科长。HMC将提供专业知识、技术援助、 和小鼠进行人到小鼠的异种移植研究。MSCTC将提供培训和技术 协助研究小鼠的造血和良性血液学问题。人性化的鼠标 CORE将促进对免疫缺陷小鼠的人到小鼠的异种移植研究。作为一项独特的功能 耶鲁大学HMC将为血液学研究人员提供获得新型人源化免疫缺陷小鼠的机会，这些小鼠经过优化 支持人类造血干细胞、三系造血、成熟髓系细胞、红细胞和血小板 在循环中，和一个功能正常的人类免疫系统。小鼠干细胞移植核心将提供 在小鼠血液学问题研究方面的技术专长。MSCTC将提供培训和专业知识 为研究小鼠的造血和血液病，使用造血细胞移植和 功能分析。动物模型核心将成为YCCEH不可或缺的一部分。它将提供血液学 能够使用最先进技术进行体内造血和血液学研究的研究人员 疾病。它将以经济的方式提供教学、专业知识和资源。其核心将支持基本 科学和翻译研究是了解和治疗血液病的关键。

PROJECT SUMMARY/ The mission of the Animal Modeling Core (AMC) is to provide research groups within the YCCEH and the larger scientific community access to the latest technologies for hematologic studies in animal models. In vivo studies allow researchers to ask questions about the function of molecules, cell populations, and tissues within the relevant spatial and temporal contexts. The YCCEH will continue to provide scientists training and facilitate research in mouse models of hematologic diseases. Importantly, the AMC will continue to develop and propagate the most innovative humanized mouse models for the study of human hematopoiesis and diseases thereof with the goal to overcome major shortcomings of current models. The AMC consists of two cores, the Humanized Mouse Core (HMC) and the Murine Stem Cell Transplantation Core (mSCTC). The Animal Modeling Core will be directed by Dr Richard Flavell, Sterling Professor of Immunobiology and co-directed by Dr. Stephanie Halene, Associate Professor and Acting Section Chief of Hematology. The HMC will offer expertise, technical assistance, and mice for human-into-mouse xenotransplantation studies. The mSCTC will offer training and technical assistance in the study of hematopoiesis and benign hematologic questions in mice. The Humanized Mouse Core will facilitate human-into-mouse xenotransplantation studies into immunodeficient mice. As a unique feature the Yale HMC will offer hematology researchers access to novel humanized immunodeficient mice optimized to support human hematopoietic stem cells, trilineage hematopoiesis, mature myeloid cells, red cells and platelets in circulation, and a functional human immune system. The Murine Stem Cell Transplantation Core will provide technical expertise in the study of hematologic questions in mice. The mSCTC will offer training and expertise for the study of hematopoiesis and hematologic diseases in mice using hematopoietic cell transplantation and functional assays. The Animal Modeling Core will be an integral part of the YCCEH. It will provide Hematology researchers with access to state-of-the-art technologies for in vivo studies of hematopoiesis and hematologic diseases. It will provide teaching, expertise, and resources in an economical way. Its cores will support basic science as well as translational studies, key to understanding and cure of hematologic diseases.