NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD Course)

项目摘要 迫切需要改进阿尔茨海默病和相关痴呆症的治疗方法。批判性 肩负着开发治疗和遏制ADRD对公共健康影响的使命的将是新一代 ADRD科学家，特别是具有设计和实施临床所需的独特培训和技能的科学家 审判。这种培训很少通过传统的医学或生物统计学课程提供。 此外，为了改进ADRD的治疗方法，临床试验中的多学科专业知识将是必要的， 包括医学专家，但也有生物统计学、生物标记物、试验设计、参与者招募、 学习组织，研究审判伦理。这项提议要求支持第一个此类培训计划 设计和实施ADRD试验的基本要素，将利用 阿尔茨海默氏症临床试验联盟(ACTC)和每年进行一次，以使各种不同的 临床医生、科学家和研究人员接受有关ADRD临床试验的现代和强有力的培训。

Project Summary There is an urgent need for improved therapies for Alzheimer’s Disease and Related Dementias (ADRD). Critical to the mission to develop treatments for and curb the public health impact of ADRD will be a new generation of ADRD scientists, especially scientists with the unique training and skills necessary to design and perform clinical trials. This training is rarely provided through the traditional course of medical or biostatistical education. Moreover, to develop improved therapies for ADRD, multidisciplinary expertise in clinical trials will be necessary, including medical specialists but also expertise in biostatistics, biomarkers, trial design, participant recruitment, study organization, and trial ethics. This proposal requests support for a first-of-its-kind training program in the essential elements of design and conduct of ADRD trials that will leverage the full infrastructure and expertise of the Alzheimer’s Clinical Trials Consortium (ACTC) and be conducted annually to enable a diverse range of clinicians, scientists and researchers to receive modern and robust training on ADRD clinical trials.