Training Grant in Genomic Analysis and Interpretation

项目摘要/摘要 现代基因组计划极大地增加了遗传和相关生物医学数据的数量 可供研究人员使用。将快速发展的基因组技术和其他技术产生的大量数据 将生物医学数据源转化为可操作的知识是21世纪最大的科学挑战之一 世纪之交。这将需要新一代科学家接受生物、数学和计算方面的培训 科学来推动我们国家的基因组议程。同样重要的是，让一批科学家 他们需要的工具和技能，不仅在他们的研究和分析工作中，而且在他们的 事业和生活。我们的目标是继续培养一批具有研究和职业生涯的多样化的学生 在这个现代的、数据驱动的生物医学研究时代，蓬勃发展所需的技能。我们预计我们的实习生将 推进生物医学知识，以我们只能模糊预见的方式影响公众健康。 GATP不仅仅是为我们的学员提供资金的机制。这是一个有明确研究和 职业培训目标和途径。很少有大学拥有研究基础设施和人力资源 在加州大学洛杉矶分校开展尽可能大的基因组培训计划的资源。尖端的汇聚 基因组技术，世界级的计算资源，杰出的基础和临床研究人员，以及 一所高评级的教育机构使我们能够吸引和培养最高素质的学生。 我们计划更新的基因组分析培训计划每年将支持10名博士前学员 来自不同的学科。学生将获得为期两年的支持，条件是在 计划和他们的研究。已完成该计划的人员将被鼓励继续参加 在加州大学洛杉矶分校的整个时间里都在进行培训活动。该计划的课程课程提供了严谨和 生物、计算和统计科学方面的综合基础。核心课程包括 分子生物学、人类遗传学、概率论、统计学、生物信息学和生物医学伦理学等课程。至 帮助学生在当今快速发展的跨学科科学时代建立成功的研究职业生涯， 该计划还强调关键沟通、协作和职业方面的培训和资源 开发技能。我们多样化的培训人员来自加州大学洛杉矶分校的多个部门和学科；所有人都 在研究和指导学生方面都有良好的记录。在这次更新中，我们进行了全面的 使用我们受训人员的反馈、科学知识的进步和适用情况对该计划进行评估 教育理论。在此评估的基础上，我们对计划进行了修订，以提高学生的整体素质 培训经验。我们相信，这将使我们能够继续培养优秀的学员，这些学员将离开该项目 具有追求和支持独立研究事业的知识和技能，并培训和指导 下一代科学家。我们的学员将对生物医学研究和国家的 未来几十年的健康目标。

Project Summary/Abstract Modern genome projects have dramatically increased the amount of genetic and associated biomedical data available to researchers. Turning the flood of data generated by rapidly evolving genomic technologies and other biomedical data sources into actionable knowledge is one of the greatest scientific challenges of the 21st Century. It will take a new generation of scientists trained in the biological, mathematical, and computational sciences to push forward our nation’s genomic agenda. It is also important to prepare a cohort of scientists with the tools and skills they need to thrive, not only in their research and analytical endeavors, but also in their careers and lives. Our objective is to continue to train a diverse cohort of students with the research and career skills needed to thrive in this modern, data-driven era of biomedical research. We anticipate that our trainees will advance biomedical knowledge and impact public health in ways that we can only dimly foresee. The GATP is much more than a funding mechanism for our trainees. It is a program with clear research and career training objectives and approaches. Few universities have the research infrastructure and human resources to mount a genomic training program of the scope possible at UCLA. The convergence of cutting edge genomic technologies, world-class computing resources, an outstanding basic and clinical research faculty, and a highly rated educational institution allows us to attract and train students of the highest caliber. Our proposed renewal of the Genomic Analysis Training Program will support ten predoctoral trainees per year from a variety of disciplines. Students will be supported for two years, contingent on sustained progress in the program and their research. Those who have completed the program will be encouraged to continue to join the training activities throughout their time at UCLA. The program course curriculum provides a rigorous and comprehensive foundation in the biological, computational and statistical sciences. The core curriculum includes courses in molecular biology, human genetics, probability, statistics, bioinformatics, and biomedical ethics. To help students build successful research careers in the current era of rapidly evolving, interdisciplinary science, the program also emphasizes training and resources in critical communication, collaboration, and career development skills. Our diverse training faculty come from multiple UCLA departments and disciplines; all have strong records in both research, and mentoring students. In this renewal we have undertaken a comprehensive evaluation of the program, using feedback from our trainees, advances in scientific knowledge, and applicable education theory. Based on this evaluation, we have revised the program to improve the overall quality of the training experience. We believe this will allow us to continue to produce excellent trainees who leave the program with the knowledge and skills to pursue and support independent research careers, and train and mentor the next generation of scientists. Our trainees will make a substantial impact on biomedical research and the nation’s health goals for decades to come.