Biomechanics in Regenerative Medicine (BiRM) Training Program

这是一个新的申请，要求继续支持一个独特的、充满活力的、多机构和多学科的预科 博士生培训项目“再生医学中的生物力学(BIRM)” 匹兹堡大学生物工程系和卡内基梅隆大学生物医学工程系 大学。在过去的16年里，38名实习生获得了坚实的基础，这些基础导致了他们的独立职业生涯 在学术界(n=10)、工业界(n=24)和政府(n=4)，目前有另外七(7)名学员 已注册。BIRM是一个创新的训练计划，深入关注应用的多尺度生物力学 用于组织(和器官？)发育或修复的再生医学他的主要生理特征是 功能是机械的。随着再生医学领域的成熟，有必要武装下一代 工程技术人员对多尺度生物力学有了更深入的了解，二者之间的关系 生物力学和生长和重塑(机械生物学)，以及修复和再生的生物学基础。 为了实现这些目标，我们还将用现代工程技术方面的技能来磨练学员(例如， 人工智能(AI)、机电一体化、机器人、计算、过程控制和制造)。伯尔姆 利用两所主要大学的不同优势和资源的教学和研究经验 加上世界级医疗中心的临床经验，所有这些中心都毗邻而不需要行政管理 传统跨机构项目中的障碍。 实习生候选人主要来自生物工程，但我们也欢迎来自其他学科的候选人。另一个 BIRM的独特之处在于为学员(包括强制性临床导师)提供了显著的临床风险 帮助理解翻译再生医学的巨大潜力、机遇和挑战 技术。同样，生物制造和大规模生产中的挑战和机遇 再生医学技术将通过我们与 先进再生制造研究所。提供专业和职业发展，包括 创新创业。 在接下来的五年里，我们的目标是保持每年6个博士前奖学金。我们的多机构计划将 为我们的学员提供一个独特的机会，让他们1)培养多学科的关键协作技能 衡量生物力学，2)使他们做好准备，随着领域的发展进入未来的再生医学劳动力 从概念到现实，3)成为企业上游研究和下游生产的创新者 下一代技术。

This is a new application for continued support of a unique, vibrant, multi-institutional and multi-disciplinary pre- doctoral training program entitled “Biomechanics in Regenerative Medicine (BiRM)” jointly run by the Departments of Bioengineering at the University of Pittsburgh and Biomedical Engineering at Carnegie Mellon University. For the past 16 years, 38 trainees have gained a solid foundation that has led to independent careers in academia (n=10), industry (n=24), and government (n=4) with an additional seven (7) trainees currently enrolled. BiRM is an innovative training program with an in depth focus on multi-scale biomechanics as applied to regenerative medicine for the development or repair of tissues (and organs?) whose primary physiological function is mechanical. As the field of regenerative medicine matures, it is necessary to arm the next generation engineering workforce with a deeper understanding of multi-scale biomechanics, the relationship between biomechanics and growth and remodeling (mechanobiology), and the biological basis of repair and regeneration. To accomplish these, we will also hone our trainees with skills in contemporary engineering technologies (e.g., artificial intelligence (AI), mechatronics, robotics, computation, process control, and manufacturing). BiRM leverages the didactic and research experiences of distinct strengths and resources of two major universities plus clinical experience of a World-class medical center all located adjacent to one another without administrative roadblocks in conventional cross-institutional programs. Trainee candidates are primarily from bioengineering, but we also welcome those from other disciplines. Another unique aspect of BiRM is the significant clinical exposure for trainees (including a mandatory clinical mentor) to aid in appreciation of the enormous potential, opportunity, and challenge of translating regenerative medicine technologies. Similarly, challenges and opportunities in biomanufacturing and large-scale production of regenerative medicine technologies will be imparted to the trainees with our unique partnership with the Advanced Regenerative Manufacturing Institute. Professional and career development are offered, including innovation and entrepreneurship. In the next five years, we aim to maintain 6 pre-doctoral fellowships per year. Our multi-institutional program will provide a unique opportunity for our trainees to 1) develop key collaborative and multidisciplinary skills on multi- scale biomechanics, 2) to prepare them to enter the future regenerative medicine workforce as the field moves from conception to reality, and 3) to become innovators in upstream research and downstream production for the next generation of technologies.