Center for Cancer Biology Research

这项Cobre第三阶段申请旨在继续支持癌症生物学研究中心 (CCBR)在南达科他州苏福尔斯的桑福德研究中心建立了一个强大的研究项目。这个 CCBR的最初使命是建立和发展癌症研究，重点是基础和 翻译活动。在第一阶段Cobre资助期间，与五个项目负责人一起建立了CCBR。 重要的是，开发了以科学核心形式的关键基础设施，并实施了试点赠款方案 被启动了。第一阶段的成功标志着项目负责人获得了R01级资金 毕业于Cobre Funding，并一直成功到今天。此外，项目负责人还发布了 同行评议期刊和科学核心功能中的重要科学论文开始扩大 他们的专业知识。试点赠款计划的力量通过科学出版物和获得 由获奖者提供资金。这些里程碑使Cobre为CCBR提供第二阶段资金成为可能。 虽然CCBR的使命保持不变，但涌入CCBR的医生/科学家促使 对转化性癌症研究的广泛关注；一个仍然强烈存在的主题。第二期工程 领导人也成功地获得了外部资金，并从科布雷的支持中毕业。此外， 科学核心进一步扩大了他们的服务，并开始采用更系统的方法(SmartSheets)来 向用户订购、跟踪和报告服务。此外，还制定了按服务收费的明细表 科学核心们正在为实现自给自足做准备。试点赠款方案继续 向利用这些资源成功发表和获得资金的调查人员提供资金。阶段 III Cobre资金将使CCBR的科学核心达到自我维持的状态，同时 继续为CCBR成员以及Sanford Research的非CCBR成员提供关键服务 以及来自地区和国家机构的调查人员。此第三阶段应用程序的一个关键组件将 为CCBR的试点赠款计划提供资金。这些试点赠款已证明是以下项目的基本资金来源 新的研究人员和更有经验的教职员工希望测试创新假设或需要资源 生成获得外部资金所需的数据。从历史上看，CCBR的飞行员获奖者 证明了这种资助导致了同行评审的科学出版物，并使它们能够获得 来自外部来源的资金。此外，很大比例的试点资助项目利用CCBR的科学 因此，这些核心有助于它们的自我可持续性。CCBR在科布雷过去十年的成功 融资证明了这一融资机制的变革性力量。获得最后阶段的 科布雷基金将进一步加强科学核心、翻译研究、科学文化 创新科学和CCBR的研究基础设施，始于科布雷第一阶段资金。

This CoBRE Phase III application aims to continue support for the Center for Cancer Biology Research (CCBR) which has established a strong research program within Sanford Research, Sioux Falls, SD. The original mission of the CCBR was to establish and grow cancer research with a focus on basic and translational activities. During Phase I CoBRE funding, the CCBR was established with five Project Leaders. Importantly, critical infrastructure, in the form of Scientific Cores, was developed and a Pilot Grant Program was initiated. The success of Phase I was marked by attainment of R01 level funding by Project Leaders who graduated from CoBRE funding and remain successful to this day. In addition, Project Leaders published important scientific papers in peer-reviewed journals and the Scientific Core functions began expanding as did their expertise. The power of the Pilot Grant program was demonstrated by scientific publications and obtaining of funding by awardees. These milestones enabled the awarding of CoBRE Phase II funding for the CCBR. While the missions of the CCBR remained unchanged, the influx of physician/scientists to the CCBR prompted an extensive focus on translational cancer research; a theme that remains strongly in place. Phase II Project Leaders were also successful in obtaining extramural funding and graduated from CoBRE support. Moreover, the Scientific Cores further expanded their services and began a more systematic approach (SmartSheets) to order, track and report back services to their users. In addition, fee-for-service schedules were developed for the Scientific Cores as they prepared for attaining self-sufficiency. The Pilot Grant program continued to provide funding to investigators who utilized these resources to successfully publish and obtain funding. Phase III CoBRE funding will enable the CCBR's Scientific Cores to reach a state of self-sustainability while continuing to offer critical services to CCBR members as well as non-CCBR members of Sanford Research and investigators from regional and national institutions. A critical component of this Phase III application will fund the CCBR's Pilot Grant Program. These Pilot Grants have proven to be essential sources of funding for new investigators and more seasoned faculty that want to test innovative hypotheses or require resources to generate data necessary to secure extramural funding. Historically, the CCBR's Pilot Grant Awardees have demonstrated that this funding results in peer-reviewed scientific publications and enables them to obtain funding from external sources. Moreover, a large percent of Pilot Grant projects utilizes the CCBR's Scientific Cores thereby contributing to their self-sustainability. The CCBR's successes over the past decade of CoBRE funding are a testament to the transformative power of this funding mechanism. Obtaining the final Phase of CoBRE funding will further strengthen the Scientific Cores, translational research, scientific culture of innovative science and the research infrastructure of the CCBR that began with Phase I CoBRE funding.