Training Program in Neurobiology of Information Storage

项目总结 本申请旨在续订信息存储神经生物学培训计划(NISTP)，该计划是 致力于为优秀的博士前学生在学习科学方面的研究密集型职业做准备 和记忆。该计划自2003年开始实施，重点是基本信息机制方面的培训 动物和人类的储存，是西北大学这一领域研究的中心组织者。使用 最近心理健康研究向基于系统的维度框架的转变，有 对通过该计划提供的这类培训的需求前所未有，该计划提供多个 了解学习和记忆的机制及其与心理健康的相关性的分析水平。 NISTP基于西北大学跨部门神经科学(NUIN)计划， 从一个由31名互动调查人员组成的多学科小组中脱颖而出，他们成功地参与了 分子/遗传、细胞/回路和系统/行为决定因素的合作研究 信息存储。NISTP导师在博士前培训方面有很好的记录，资金充足 研究计划，可以向一群优秀的发展中的人传授基础和临床观点 科学家。NISTP的培训部分将包括：1)关于最新研究的高级课程 信息存储神经生物学，由NISTP讲师授课；2)两个由学员主办的讲座系列，内容包括 信息存储领域的领先研究人员；3)为准备NRSA的学员提供模拟学习部分 申请；以及4)NISTP季度会议，包括a)“正在进行的研究”实习生讲座，b)“长凳到 床边“翻译讨论”，c)“计算建模和记忆”互动讨论，以及d) NISTP年度务虚会。NISTP还服务于对学生进行科学伦理教育并招收学生 从代表不足的群体到研究学习和记忆。将对该计划进行持续评估 使用定性机制，如学员及其导师的评估，以及 量化措施，如跟踪以前的研究生产率、资金和职业轨迹 实习生。内部指导委员会和外部咨询委员会将进行额外的 评估流程。学员主要从NUIN学生中挑选出来，这些学生完成了 并在论文研究方面取得了重大进展。我们要求继续 支持5个受训人员时段，并补充1个机构资助的“附属机构”时段。与 NISTP的附加值，我们相信NISTP学员将从他们的研究生培训中脱颖而出 准备推进学习和记忆的基本生物学机制的研究，并处于有利地位 开发新的翻译应用程序。

PROJECT SUMMARY This application seeks to renew the Neurobiology of Information Storage Training Program (NISTP), which is devoted to preparing exceptional predoctoral students for research-intensive careers in the science of learning and memory. Active since 2003, the program is focused on training in fundamental mechanisms of information storage in animals and humans, acting as a central organizer for research in this area at Northwestern. With the recent shift in mental health research toward dimensional, systems-based frameworks, there is unprecedented need for training of the kind offered through this program, which provides training at multiple levels of analyses for understanding mechanisms of learning and memory and their relevance to mental health. The NISTP is based in the Northwestern University Interdepartmental Neuroscience (NUIN) program, emerging from a multidisciplinary group of 31 interactive investigators who have successfully engaged in collaborative research on molecular/genetic, cellular/circuit, and systems/behavioral determinants of information storage. NISTP preceptors have strong track records in predoctoral training and well-funded research programs, and can impart both basic and clinical perspectives to a group of outstanding developing scientists. Training components of the NISTP will include: 1) an advanced course in the latest research in information storage neurobiology, taught by NISTP preceptors; 2) two trainee-hosted lecture series featuring leading investigators in the field of information storage; 3) mock study sections for trainees preparing NRSA applications; and 4) quarterly NISTP meetings including a) “research in progress” trainee talks, b) “bench to bedside” translational discussions, c) “computational modeling and memory” interactive discussions, and d) the annual NISTP retreat. NISTP also serves to educate students in the ethics of science and to recruit students from underrepresented groups to study learning and memory. Continuous evaluation of the program will be accomplished using qualitative mechanisms, such as evaluations by trainees and their mentors, and quantitative measures, such as tracking the research productivity, funding, and career trajectories of former trainees. An internal Steering Committee and an External Advisory Committee will conduct additional assessment processes. Trainees are drawn primarily from a pool of NUIN students who have completed most of the required coursework and have made significant progress in their thesis research. We request continued support for five trainee slots, which will be supplemented with one institutionally funded “affiliate” slot. With the value added by the NISTP, we are confident that NISTP trainees will emerge from their graduate training poised to advance research in fundamental biological mechanisms of learning and memory and well positioned to develop novel translational applications.