Training of the Pediatric Physician-Scientist

项目总结/摘要 该提案是儿科医生-科学家T32支持的第三次更新申请 在华盛顿大学医学院（WUSM）儿科（DOP）的培训计划。 儿科医生-科学家在促进改善儿童健康的知识方面发挥着至关重要的作用。满足 持续的国家需要补充儿科医生-科学家管道在临床博士后 奖学金级别，我们的计划支持每年4名学员的指导职业发展途径 （通常为期2年），利用WUSM的丰富生物医学研究资源 校园，DOP和我们的儿童健康研究中心（NICHD CHRCDA K12）。在过去的20年里， 展望未来，该计划的长期目标是培养那些专注于研究工作的受训人员 通过应用基础科学和转化科学的最新进展， 如发育生物学、细胞生物学、免疫学、遗传学、多组学系统生物学和生物信息学。 这项建议的具体目标包括：1）一个受保护的指导研究经验， 在WUSM和DOP内与儿童健康相关的广泛学科的调查员，2）强制性 实验室管理，科学严谨性，统计学，granecraft，负责的教育计划 研究和生物医学信息学的行为，3）基于学员区域的个性化课程 调查（例如，遗传学、细胞生物学、计算生物学），4）对受训者的持续反馈， 导师和项目领导，以及5）灵活的环境，促进培训生的发展， 是妇女，是代表性不足的少数民族。该计划，现在20岁，有一个很好的轨道 通过超过国家基准（15年T到K转换率= 52%;本周期= 57%），并将 最终缩小基础/转化科学家和儿科临床医生之间的知识差距。加里A. 西尔弗曼医学博士，哲学博士、和医学博士大卫·亨斯塔德再次担任项目主任，培训 导演，分别。我们的学员将继续利用大量的机构资助，国家的最先进的 研究核心设施，提供例如全基因组/外显子组DNA测序，单细胞RNA 测序，诱导多能干细胞和类器官，生物信息学，冷冻EM和其他先进的 成像，CRISPR-CAS9基因组编辑和模型动物开发，以促进儿科研究 疾病状态。该计划的长期目标正在实现，因为它的学员有助于我们的 了解未来几十年的发展和儿童疾病，同时发展到下一个 一代科学领导者，榜样，和导师的后代儿科医生- 科学家

PROJECT SUMMARY/ABSTRACT This proposal is the third renewal application for support of the Pediatric Physician-Scientist T32 training program in the Department of Pediatrics (DOP) at Washington University School of Medicine (WUSM). Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national need to replenish the pediatric physician-scientist pipeline at the clinical post-postdoctoral fellowship level, our program supports a mentored career development pathway for 4 Trainees per year (typically for 2 years each) by leveraging a wealth of biomedical research resources across the WUSM campus, the DOP and our Child Health Research Center (NICHD CHRCDA K12). For the past 20 years and going forward, the long-term objective of this program is to develop Trainees who focus their research efforts on pediatric disease-oriented biology by applying recent advances in the basic and translational sciences, such as developmental biology, cell biology, immunology, genetics, multi-omics systems biology, and bioinformatics. The specific aims of this proposal include: 1) a protected mentored research experience with a well-established investigator across a wide range of disciplines related to child health within WUSM and the DOP, 2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship, responsible conduct of research, and biomedical informatics, 3) individualized coursework based on the Trainees area of investigation (e.g., genetics, cell biology, computational biology), 4) continuous feedback to the Trainee, mentor and program leadership, and 5) a flexible environment that facilitates the development of Trainees who are women and are under-represented minorities. The program, now 20 years old, has an excellent track record by exceeding national benchmarks (15-year T to K conversion rate = 52%; this cycle = 57%), and will ultimately close the knowledge gap between basic/translational scientists and pediatric clinicians. Gary A. Silverman, M.D., Ph.D., and David Hunstad, M.D. again serve as the Program Director, and the Training Director, respectively. Our Trainees will continue to utilize a vast array of institutionally funded, state-of-the-art research core facilities that provide, for example, whole-genome/exome DNA sequencing, single-cell RNA sequencing, induced pluripotent stem cells and organoids, bioinformatics, cryo-EM and other advanced imaging, CRISPR-CAS9 genome editing and model animal development, to facilitate the study of pediatric disease states. The long-term goals of this program are being realized as its Trainees contribute to our understanding of development and childhood diseases for decades to come, while evolving into the next generation of scientific leaders, role models, and mentors for subsequent generations of pediatric physician- scientists.