课题基金 / 基金详情

Training in Environmental Toxicology

Training in Environmental Toxicology
环境毒理学培训
批准号:
10628202
负责人:
Alison Elder
金额:
$74.13万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1978
资助国家:
美国
项目状态:
未结题
起止时间:
1978-07-01 至 2028-06-30

项目摘要

项目成果

Alison Elder的其他基金

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中文摘要
翻译
要求提供资金支持罗切斯特毒理学培训计划。有紧迫的社会问题 需要识别和评估不断增加的环境化学、物理、 和社会压力对人类健康的影响。该项目的总体目标是提供博士后和博士后 培训下一代有才华的独立毒物学家和环境健康科学家 批判性思维能力,能够进行新的研究,并积极转化他们的发现,并从 其他的,变成了新的信息。这些信息随后将被翻译,供科学家、公共卫生和 医疗专业人员、政府和其他机构以及公众,以改善整体人类健康和 幸福。该计划的特点是其特殊的毒理学培训环境,这是显而易见的 由于之前学员的成功,教职员工之间非凡的合作和广泛的合作 培训人员,广泛的研究支持基础,以及强大的领导力和机构承诺。该计划 致力于满足不同背景学员的需求,支持他们的个性化目标 在学术界、政府和工业界的职业生涯。该计划的框架是基于这样的理念: 对未来劳动力的培训需要多学科和跨学科的方法,密切合作 学员与他们的指导团队之间的关系,以及支持多样性、自主性和 职业发展。该计划利用了广泛的专业知识和资源,可在 主要的学术医学中心超越了单一的科室。该计划位于 环境医学系,然而31名教员导师来自13个基础科学和临床 罗切斯特大学医学院和牙医学院内的系和科。教研室研究 涵盖了整个毒理学领域,从分子机制和细胞过程到整个动物 和人类人口。有7个重点研究领域(神经毒理学和行为毒理学, 肺和心血管毒理学、发育和生殖毒理学、免疫毒理学 肌肉骨骼毒理学、皮肤毒理学和内分泌毒理学)植根于当代 主题包括颗粒物和空气污染,毒性的分子遗传修饰物,发育起源 健康与疾病、表观遗传调控系统以及疾病的社会决定因素。该计划还 与其他培训方案以及研究和专业发展支持中心紧密结合 在大学里。在本培训补助金的当前周期内,对教学课程进行了改进 通过了,增加了新的环境健康研究专门知识,发起了公平和多样性倡议, 并修订了招募和留住不同背景受训人员的战略。继续支持 罗切斯特毒理学培训计划将确保可靠的特别精心准备的博士- Level毒理学家将做好准备,满足当今健康科学工作者日益增长的需求。
英文摘要
Funds are requested to support the Rochester Toxicology Training Program. There are pressing societal demands to identify and evaluate the impact of an ever-increasing array of environmental chemical, physical, and social stressors on human health. The overall objective of this Program is to provide pre- and postdoctoral training for the next generation of talented, independent toxicologists and environmental health scientists with critical thinking skills who will conduct novel research and actively transform their findings, and findings from others, into new information. This information will then be translated for use by scientists, public health and medical professionals, governmental and other agencies, and the public to improve overall human health and well-being. This Program is distinguished by its exceptional environment for training in toxicology, as evidenced by the success of prior trainees, the remarkable collegiality and extensive collaborations amongst faculty and trainees, a broad base of research support, and its strong leadership and institutional commitment. The Program is dedicated to meeting the needs of trainees from diverse backgrounds and supporting their individualized goals for careers in academia, government, and industry. The Program’s framework is based on the philosophy that training for the future workforce requires multidisciplinary and interdisciplinary approaches, close working relationships between trainees and their mentoring teams, and a culture that supports diversity, autonomy, and career development. The Program takes advantage of extensive expertise and resources that are available at a major academic medical center by reaching beyond a single department. The Program is housed in the Department of Environmental Medicine, yet the 31 faculty mentors come from 13 basic science and clinical departments and divisions within the University of Rochester School of Medicine and Dentistry. Faculty research spans the entire spectrum of toxicology, from molecular mechanisms and cellular processes to whole animals and human populations. There are 7 keystone research areas (Neurotoxicology and Behavioral Toxicology, Pulmonary & Cardiovascular Toxicology, Developmental & Reproductive Toxicology, Immunotoxicology, Musculoskeletal Toxicology, Dermal Toxicology and Endocrine Toxicology) that are rooted in contemporary themes that include particles and air pollution, molecular-genetic modifiers of toxicity, developmental origins of health and disease, epigenetic regulatory systems, and social determinants of disease. The Program is also tightly integrated with other training programs, as well as research and professional development support centers at the University. During the current cycle of this training grant, refinements to the didactic curriculum were adopted, new environmental health research expertise was added, equity and diversity initiatives were launched, and strategies to recruit and retain trainees from diverse backgrounds were revised. Continued support of the Rochester Toxicology Training Program will ensure that a reliable stream of exceptionally well-prepared PhD- level toxicologists will be ready to meet the growing demands of the today’s health science workforce.
期刊论文(49)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1210/mend.9.1.7539106
发表时间: 1995
期刊: Molecular endocrinology
影响因子: --
作者: [S. F. Arnold;J. Obourn;H. Jaffe;A. Notides]
通讯作者: S. F. Arnold;J. Obourn;H. Jaffe;A. Notides
Postnatal administration of S-adenosylmethionine restores developmental AHR activation-induced deficits in CD8+ T cell function during influenza A virus infection.
出生后给予 S-腺苷甲硫氨酸可恢复甲型流感病毒感染期间发育性 AHR 激活诱导的 CD8 T 细胞功能缺陷。
DOI: 10.1093/toxsci/kfad019
发表时间: 2023
期刊: Toxicological sciences : an official journal of the Society of Toxicology
影响因子: --
作者: [Post,ChristinaM, Myers,JasonR, Winans,Bethany, Lawrence,BPaige]
通讯作者: Lawrence,BPaige
The effect of lung alpha-tocopherol content on the acute toxicity of nitrogen dioxide.
肺α-生育酚含量对二氧化氮急性毒性的影响。
DOI: 10.1016/0041-008x(86)90138-9
发表时间: 1986
期刊: Toxicology and applied pharmacology
影响因子: 3.8
作者: [Guth,DJ, Mavis,RD]
通讯作者: Mavis,RD
Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element.
人雌激素受体上酪氨酸 537 的磷酸化是与雌激素反应元件结合所必需的。
DOI: 10.1074/jbc.270.50.30205
发表时间: 1995
期刊: The Journal of biological chemistry
影响因子: --
作者: [Arnold,SF, Vorojeikina,DP, Notides,AC]
通讯作者: Notides,AC
共 31 条
    Glymphatic impairment as a crucial factor in particulate matter exposure related development of Alzheimer's disease pathology
    • 批准号:
      10718104
    • 项目类别:
    • 资助金额:
      $73.39万
    • 财政年份:
      2023
    • 负责人:
      Alison Elder
    • 依托单位:
    International Nanotoxicology Congress: Nanotox 2016
    • 批准号:
      9195226
    • 项目类别:
    • 资助金额:
      $0.8万
    • 财政年份:
      2016
    • 负责人:
      Alison Elder
    • 依托单位:
    Impact of Ambient Ultrafine Particle Exposures on Alzheimer's Disease Progression
    • 批准号:
      9065942
    • 项目类别:
    • 资助金额:
      $34.2万
    • 财政年份:
      2013
    • 负责人:
      Alison Elder
    • 依托单位:
    Impact of Ambient Ultrafine Particle Exposures on Alzheimer's Disease Progression
    • 批准号:
      8502926
    • 项目类别:
    • 资助金额:
      $34.2万
    • 财政年份:
      2013
    • 负责人:
      Alison Elder
    • 依托单位:
    海外基金