Guiding epilepsy surgery using network models and Stereo EEG

家长助学金摘要 家长赠款的目标是将针对癫痫手术的方法转化为临床实践。那里 显然需要标准化、量化的方法来绘制癫痫网络图，并对其进行定位和优化 心理治疗。这些工具一旦得到验证，将极大地改善临床护理和生活质量。要翻译我们的 方法尽快进行临床试验我们将需要解决三个主要挑战：(1)适应我们的 方法：(2)消除稀疏电极的采样误差；(3) 在多个中心的大量患者身上验证了我们的方法。为了应对这些挑战， 拟议的工作将：(1)用有效的、人工的方法取代目前指导癫痫手术的不精确的方法， 将使这些程序标准化的严格的量化工具；(2)消除加速缉获的需要 要绘制网络图，(3)提供工具来模拟不同大脑干预的效果，以优化治疗；(4) 开发优化SEEG植入物、消除电极采样误差和改进患者选择的方法 进行侵入性治疗。最后，我们勾勒出一条通往临床翻译的道路，一项预期的临床试验，以及 了解癫痫发作发生的潜在机制。

Summary of Parent Grant The objective of the parent grant is to translate methods to target epilepsy surgery into clinical practice. There is a clear need for standardized, quantitative methods to map epileptic networks and to target and optimize therapy. These tools, once validated, will dramatically improve clinical care and quality of life. To translate our methods to clinical trials as fast as possible we will need to address 3 major challenges: (1) adapting our methods to Stereotactic EEG (SEEG), (2) eliminating sampling error from sparse electrode implants, and (3) validating our methods on a larger number of patients across centers. To address such challenges the proposed work will: (1) replace current imprecise, manual methods for guiding epilepsy surgery with validated, rigorous quantitative tools that will standardize these procedures; (2) eliminate the need to precipitate seizures to map networks, (3) provide tools to simulate the effects of different brain interventions to optimize therapy; (4) develop methods to optimize SEEG implants, eliminate electrode sampling error, and improve patient selection for invasive treatment. Finally, we outline a path to clinical translation, a prospective clinical trial, and understanding mechanisms underlying seizure generation.