BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAM

Together Senior Health，Inc.（一起）是一个妇女拥有的小企业，致力于帮助老年人 认知能力下降或阿尔茨海默病及相关痴呆（ADRD）的成年人维持生活质量， 通过提供创新的，基于证据的，在线的，直播的，小组计划的独立性。我们的第一个产品 Together音频/视频平台是Moving TogetherTM，它结合了各种运动， 功能与正念身体意识练习和社会参与，并专为轻度 ADRD和他们的护理人员一起在家参加。我们第二阶段的主要目标小 商业创新研究（SBIR）赠款是通过开发和测试一个 针对轻度认知障碍患者的全面脑健康计划 （MCI）。没有药物可以预防MCI患者发生ADRD;但是， 越来越多的证据表明，针对可改变的痴呆症风险因素的行为干预措施-如身体 不活动、社交孤立和抑郁--可能有助于改善认知功能， 痴呆发作我们的初步结果表明，我们的产品，一起移动，与 认知功能、身体功能、社会隔离和自我调节方面的显著改善，以及 静息状态前/后功能性磁共振成像的默认模式网络连接增加 （rs-fMRI）扫描MCI患者。我们相信，如果共同行动，这些好处会更大 与一个全面的大脑健康指导计划相结合。我们第二阶段的具体目标是： 与我们的科学顾问委员会合作，使用以人为本的设计来开发基于证据的内容 大脑健康在一起，一个为期12周的，以小组为基础的，直播，数字计划，将结合联合收割机移动 与大脑健康指导一起，解决MCI患者中可改变的痴呆风险因素; 2）执行 一项随机对照试验，以确定大脑健康共同计划是否能改善认知能力 与成功老化对照组相比，MCI患者在12周内的功能;以及3） 确定每周的维护课程是否有助于维持大脑健康的效果 在干预后的12周内，如果我们能证明大脑健康 MCI患者的即时和持续认知益处，它将使Together成为国家领导者 在以证据为基础的计划，以提高生活质量，防止老年人的认知能力下降， 损伤技术和商业援助（TABA）资金将使Together能够获得 外部市场研究专业知识，以确定和定位我们的共同大脑健康计划 不同的潜在用户群，有针对性的信息和有意义的内容， 与每一段相关。

Together Senior Health, Inc. (TOGETHER) is a woman-owned small business that is dedicated to helping older adults with cognitive decline or Alzheimer’s disease and related dementias (ADRD) maintain quality of life and independence by offering innovative, evidence-based, online, livestream, group programs. Our first product on the TOGETHER audio/video platform is Moving TogetherTM—which combines movements to support daily function with mindful body awareness exercises and social engagement and is designed for people with mild ADRD and their caregivers who participate together from home. The primary goal of our Phase II Small Business Innovation Research (SBIR) grant is to expand our product line by developing and testing a comprehensive BRAIN HEALTH TOGETHER program for people living with mild cognitive impairment (MCI). There are no medications that can prevent development of ADRD in people with MCI; however, there is growing evidence that behavioral interventions targeting modifiable dementia risk factors—such as physical inactivity, social isolation, and depression—may help improve cognitive function and could potentially delay dementia onset. Our preliminary results suggest that our product, Moving Together, is associated with significant improvements in cognitive function, physical function, social isolation, and self-regulation as well as increased default mode network connectivity on pre/post resting state functional magnetic resonance imaging (rs-fMRI) scans in people with MCI. We believe that these benefits would be even greater if Moving Together were combined with a comprehensive brain health coaching program. Our Phase II Specific Aims are to: 1) Work with our Scientific Advisory Board and use human-centered design to develop evidence-based content for Brain Health Together, a 12-week, group-based, live-streaming, digital program that will combine Moving Together with brain health coaching to address modifiable dementia risk factors in people with MCI; 2) Perform a randomized, controlled trial to determine whether the Brain Health Together program improves cognitive function in people with MCI over 12 weeks compared to a Successful Aging comparison group; and 3) Determine whether weekly maintenance classes help to sustain the effects of the Brain Health Together program over 12 weeks after the intervention. If we can demonstrate that BRAIN HEALTH TOGETHER has immediate and sustained cognitive benefits in people with MCI, it will position TOGETHER as a national leader in evidence-based programs to improve quality of life and prevent decline in older adults with cognitive impairment. Technical and Business Assistance (TABA) funding will enable TOGETHER to access external market research expertise to identify and position our BRAIN HEALTH TOGETHER program with different potential user segments with targeted messages and meaningful content that is most relevant to each segment.