The Early Growth and Development Study Cohort of the ECHO Program

项目摘要 儿童神经发育问题的综合经济和个人影响，如行为 精神障碍、多动症、抑郁和焦虑症状都很严重。与此同时，有越来越多的 有证据表明，积极健康的各个方面可以支持儿童过上有意义的、富有成效的生活。在 目前的建议，我们解决与心理社会环境暴露的时间相关的知识差距 以及它们对儿童神经发育和积极健康的影响何时显现，以及儿童在多大年龄段面临风险 影响发展轨迹的因素和资产是最有力的。我们亦建议研究 过渡到青春期。青春期可能是儿童发展的一个转折点，因为 大脑、情绪和社会制度，然而从婴儿期到青春期的纵向研究，有大量的 来自不同背景的儿童严重缺乏。最后，儿童的神经发育和积极的健康 很少一起检查，导致对儿童心理健康的所有阶段的评估不完整 发展。这个应用程序试图通过参与 环境对儿童健康结局的影响(ECHO)儿科随访队列研究地点 程序。在此应用程序中，我们建议跟踪1,000名儿童的早期生长发育的现有样本 和发展研究(EGDS)队列，注册为ECHO计划的2级参与者和 具有从产前开始的回声队列协议数据元素。EGDS是全国范围内的样本 与养父母或亲生父母同住的儿童(S)。儿童的年龄为7-20岁， 在拟议的研究中使用回声队列协议进行年度评估。我们在以下方面取得了巨大的成功 实现我们计划的招聘和入学率，收集数据并与ECHO计划共享数据， 并在当前的回声资助周期中为回声范围的科学和手稿作出贡献。我们将在此基础上 我们的成功和基础设施通过领先的协作Echo队列为Echo的目标做出贡献 科学，双重关注ECHO队列协议核心数据元素和两个专门化的子成果 领域：神经发育和儿童积极健康。通过三个具体目标，我们将：(1)利用回声 队列议定书核心数据元素，以检查早期接触对儿童的直接和潜在影响 在不同背景下不同发展阶段的健康结果；(2)利用专门研究的数据 测试青春期神经发育变化和积极健康的预测指标的结果；以及，(3) 每季度实施数据驱动的检查点，以评估我们对现有队列参与者的保留情况， 强调协议的多样性和高保真执行。我们的总体目标是努力 与ECHO计划合作，促进对儿童预测因素和结果的了解 健康，以便为改善儿童健康的计划、做法和政策提供信息 世世代代。

Project Summary The combined economic and personal effects of children’s neurodevelopmental problems, such as conduct disorder, ADHD, and depression and anxiety symptoms are substantial. At the same time, there is growing evidence that dimensions of positive health can support children in leading meaningful, productive lives. In the current proposal we address knowledge gaps related to the timing of psychosocial environmental exposures and when their effects on child neurodevelopment and positive health emerge, and at what ages children’s risk factors and assets are most potent in affecting developmental trajectories. We also propose to examine the transition to adolescence. Adolescence can be a turning point in child development given rapid changes in the brain, emotional, and social system, yet longitudinal studies from infancy to adolescence with large cohorts of children from diverse backgrounds are sorely lacking. Last, children’s neurodevelopment and positive health are rarely examined in concert, leading to incomplete assessments of children’s mental health at all phases of development. This application seeks to fill some of these knowledge gaps through participation in the Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up Program. In this application, we propose to follow an existing sample of 1,000 children from the Early Growth and Development Study (EGDS) cohort who are enrolled as Level 2 participants in the ECHO Program and have ECHO Cohort Protocol data elements beginning in the prenatal period. EGDS is a nationwide sample of children living with either their adoptive or biological parent(s). Children will be age 7 – 20 years old and assessed annually using the ECHO Cohort Protocol in the proposed study. We have been highly successful in achieving our planned recruitment and enrollment rates, collecting and sharing data with the ECHO Program, and contributing to ECHO-wide science and manuscripts in the current ECHO funding cycle. We will build on our successes and infrastructure to contribute to ECHO’s goals through leading collaborative ECHO Cohort science, with a dual focus on ECHO Cohort Protocol core data elements and on two specialized child outcome areas: Neurodevelopment and Child Positive Health. Through three specific aims, we will: (1) leverage ECHO Cohort Protocol core data elements to examine the immediate and latent impact of early exposures on child health outcomes across different developmental periods in diverse contexts; (2) leverage data from specialized outcomes to test predictors of change in neurodevelopment and positive health in adolescence; and, (3) implement data-driven check points every quarter to assess our retention of existing cohort participants, with an emphasis on diversity and implementation of the protocol with high fidelity. Our overall goal is to work collaboratively with the ECHO Program to advance the understanding of predictors and outcomes of child health in order to inform programs, practices, and policies that will improve the health of children for generations to come.