The Early Growth and Development Study Pediatric Cohort

早期生长和发育研究儿科队列

• 批准号: 10177315
• 负责人: Jody M. Ganiban
• 金额: $ 7.17万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177315
• 关键词: Adolescence; Adolescent; Adoption; Affect; Behavioral Genetics; Child; Child Development; Complex; Data; Depression and Suicide; Development; Environmental Health; Etiology; Family; Genetic; Goals; Growth and Development function; Health Personnel; Hostility; Individual; Inherited; Life; Longevity; Mental Depression; Mentors; Modeling; Neurodevelopmental Disorder; Pediatric cohort; Prevalence; Prevention; Psychosocial Factor; Public Health; Readiness; Reading; Research; Research Activity; Research Personnel; Role; Sleep; Stress; Structure; Time; Training; Training Activity; United States; base; career; cohort; depressive symptoms; design; early adolescence; early childhood; environmental stressor; experience; genetic approach; meetings; middle childhood; parent project; peer; prenatal; prenatal influence; prevent; psychosocial; research study; skills; sleep health; socioeconomics; stressor

Abstract The proposed diversity supplement will provide the candidate training and research experiences in early psychosocial environmental influences on depressive symptoms in children and adolescents. Depression is a neurodevelopmental disorder that affects over 20 million people in the United States and is influenced by myriad prenatal/inherited, genetic, psychosocial, environmental, and health factors. Through guided readings and weekly and monthly research team meetings with mentors who have expertise in child development, depressive symptoms, longitudinal modeling, sleep health, and behavioral genetic approaches, the proposed training activities will prepare the candidate to conduct a research study that examines predictors of depressive symptoms from early childhood and adolescence. Prevalence of depressive symptoms increases dramatically between early childhood and adolescence. Accordingly, the proposed study will examine how sleep health may prevent depressive symptoms across critical developmental windows. The study will also use an ecological framework to examine interpersonal and environmental stressors during early childhood as predictors of depressive symptom trajectories. The research will look specifically at parental hostility as a microsystemic interpersonal stressor and socioeconomic stress as an exosystemic stressor, from early childhood to adolescence, as predictors of depressive symptom trajectories. We will also examine positive peer relations during middle childhood and adolescence as a protective moderator of the association between these stressors and depressive symptoms. This research will leverage the dual-family adoption design of the Early Growth and Development Study parent project (EGDS; Leve cohort, N = 1,000) and integrate data from at least two other ECHO adolescent cohorts (The Family Life Project; Blair cohort, N = 1,292; Project Viva; Oken cohort; N = 2,128). Aim 1 will examine sleep health as a time-varying predictor of depressive symptoms from early childhood to adolescence, to assess the hypothesized protective role of healthy sleep on depressive symptoms over time. Aim 2 will investigate impacts of an early childhood relationship-based stressor (parental hostility) and a structural stressor (socioeconomic stress) on depressive symptoms. Aim 3 will examine the moderating role of positive peer relations on the association between the Aim 2 stressors and children’s depressive symptoms. The long-term goal of the proposed research and training activities is to advance the candidate’s preparedness to conduct independent research focused on psychosocial factors that exacerbate or disrupt depressive symptom trajectories across the lifespan.

摘要 拟议的多样性补充将提供候选人的培训和研究经验， 早期心理社会环境对儿童和青少年抑郁症状的影响抑郁 是一种神经发育障碍，在美国影响超过2000万人， 无数的产前/遗传、遗传、心理社会、环境和健康因素。通过指导阅读 每周和每月与具有儿童发展专业知识的导师举行研究小组会议， 抑郁症状，纵向建模，睡眠健康和行为遗传学方法，建议 培训活动将准备候选人进行研究，检查抑郁症的预测因素 儿童早期和青春期的症状。 抑郁症状的患病率在幼儿期和青春期之间急剧增加。 因此，这项拟议中的研究将研究睡眠健康如何预防抑郁症状， 关键的发展窗口这项研究还将使用生态框架来研究人际关系和 儿童早期的环境压力作为抑郁症状轨迹的预测因子。研究 我将特别关注父母的敌意作为一种微观系统的人际压力和社会经济压力， 从幼儿期到青春期的外系统应激源，作为抑郁症状的预测因子 轨迹我们还将研究童年中期和青春期的积极同伴关系， 这些压力源和抑郁症状之间的关联的保护调解人。 这项研究将利用早期生长和发展研究的双家庭收养设计 母项目（EGDS; Leve队列，N = 1，000），并整合来自至少两个其他ECHO青少年的数据 队列（家庭生活项目; Blair队列，N = 1，292; Viva项目; Oken队列; N = 2，128）。目标1将 研究睡眠健康作为从儿童早期到 青少年，以评估健康睡眠对抑郁症状随时间推移的假设保护作用。 目标2将调查幼儿期基于关系的压力源（父母敌意）和 结构性压力（社会经济压力）对抑郁症状的影响。目标3将审查以下因素的调节作用： 积极同伴关系对目标2压力源与儿童抑郁症状的关系有显著影响。 拟议的研究和培训活动的长期目标是促进候选人的准备工作 进行独立的研究，重点是加剧或破坏抑郁症的心理社会因素， 整个生命周期的症状轨迹。