The Early Growth and Development Study Pediatric Cohort
早期生长和发育研究儿科队列
基本信息
- 批准号:10002317
- 负责人:
- 金额:$ 295.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-21 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescenceAdoptedAdoptionAdultAffectAgeAreaBiologicalBiological FactorsBiological MarkersBirthCharacteristicsChildChild HealthChild RearingChildhoodCodeCohort StudiesCollectionConsentDNADataDatabasesDevelopmentDietDiseaseDocumentationDrug usageEconomicsElementsEnvironmentEnvironmental ExposureEnvironmental ImpactEnvironmental Risk FactorFamilyFamily StudyFutureGeneticGenetic RiskGoalsGrowthGrowth and Development functionHealthHeritabilityHome environmentHouseholdHydrocortisoneInfrastructureInheritedLeadLifeMeasurementMeasuresMedical RecordsMental HealthMethodsModelingNeighborhoodsObesityOutcomeParentsPediatric cohortPhasePlayPregnancyPreventionProceduresProcessProtocols documentationQuantitative GeneticsRecording of previous eventsReportingResearch InfrastructureRiskRoleSalivarySamplingSampling StudiesSiblingsSocial DevelopmentSocial EnvironmentSpecimenSystemTelephoneTestingUpdateWorkadopted childcognitive developmentcohortdesignearly childhoodearly life exposureexecutive functionfollow-upgenetic analysishealth disparityimprovedindexingmemberneurodevelopmentobesity riskphysical conditioningpostnatalprenatalprospectivepsychiatric symptomrecruitretention ratesocialsocioeconomicsstressor
项目摘要
7. Project Summary/Abstract
Increasing evidence suggests that exposures from pregnancy through age 5 can result in health deficits and
lead to life-long consequences. We propose to leverage and build upon a unique existing “dual-family”
adoption design to isolate early environmental exposures from heritable influences on familial clustering of
health problems to contribute to ECHO's overall goal of investigating the role of early life exposures and
underlying biological mechanisms in childhood health and disease. Our pediatric sample will be drawn from
three cohorts of children (N = 1,201 children) who have been followed prospectively since birth in the Early
Growth and Development Study (EGDS). The EGDS cohorts consist of two types of families: adoptive families
in which the child is not genetically related to either rearing parent (n = 790 children), and biological families in
which the child is genetically related to the rearing parent (n = 411 children). Within these families, we have n =
927 sibling pairs of two types: (1) siblings living apart, in which one sibling was adopted at birth and reared with
genetically unrelated parents and the other sibling remained in the biological home and was reared by the
biological parent from birth (n = 365 pairs), and (2) siblings living together either in the adoptive home or the
biological home (n = 562 pairs). We have established a reliable research infrastructure, exceptional
measurement of the early childhood family social environment, medical records data, DNA and salivary cortisol
samples, high retention rates, and reliable and transparent data-sharing methods. We will use our well-
established prospective adoption sample to (a) help clarify causal inferences about environmental influences
on neurodevelopment and obesity, and (b) explore the unfolding interplay between inherited child
characteristics and environmental influences from birth to adolescence. In cohorts in which children are reared
by biological parents, it is difficult to differentiate the role of the social environment from that of genetic
influences. Our dual-family design addresses this fundamental confound. In this application, we emphasize the
Focus Area of Neurodevelopment; however, our sample and approach are also well suited for examining
environmental influences on Obesity and Airways Focus Areas, as secondary and tertiary foci. In the UG3
phase, we will (1) demonstrate the feasibility of rerecruiting families into ECHO by rerecruiting and consenting
families of 1,000 children; (2) prepare for the UH3 period by conducting pilot scale coding of adult medical
records, piloting our geocoding system, conducting preliminary analyses, and developing and testing a brief
measure of social environmental adversity; and (3) collaborate and plan with the ECHO Steering Committee. In
the UH3 period, we will (1) build on the UG3 activities by enhancing our assessment of environmental and
inherited risks in the EGDS cohort through in-home and phone assessments of neurodevelopment, obesity,
airway function, and the social environment; and (2) conduct ECHO consortium-wide activities as determined
by the ECHO Steering Committee.
7.项目总结/摘要
越来越多的证据表明,从怀孕到5岁的接触可能导致健康缺陷,
导致终身后果。我们建议利用和建立在一个独特的现有的“双家庭”
采用设计将早期环境暴露与对家族聚集性的遗传影响隔离开来,
健康问题,以促进ECHO的总体目标,即调查生命早期暴露的作用,
儿童健康和疾病的潜在生物学机制。我们的儿科样本将从
三个队列的儿童(N = 1,201名儿童)自出生以来一直接受前瞻性随访,
生长发育研究(EGDS)。EGDS队列包括两种类型的家庭:收养家庭
其中孩子与抚养孩子的父母没有遗传关系(n = 790名孩子),而亲生家庭则在
孩子与养育父母有遗传关系(n = 411)。在这些家庭中,我们有n =
927对兄弟姐妹,分为两类:(1)兄弟姐妹分居,其中一个兄弟姐妹在出生时被收养,
基因无关的父母和另一个兄弟姐妹仍然留在生物学上的家,由父母抚养。
出生时的亲生父母(n = 365对),以及(2)在收养家庭或
生物家园(n = 562对)。我们建立了可靠的研究基础设施,
测量幼儿期家庭社会环境、病历资料、DNA和唾液皮质醇
高保留率以及可靠和透明的数据共享方法。我们会好好利用-
建立前瞻性采用样本,以(a)帮助澄清有关环境影响的因果推断
对神经发育和肥胖的影响,以及(B)探索遗传性儿童
从出生到青春期的特征和环境影响。在孩子们被抚养长大的群体中,
通过生物学上的父母,很难区分社会环境的作用和遗传的作用。
影响。我们的双系列设计解决了这一基本混淆。在本申请中,我们强调
神经发育的重点领域;然而,我们的样本和方法也非常适合检查
环境对肥胖和气道重点领域的影响,作为第二和第三焦点。在UG 3
在第一阶段,我们将(1)通过重新招募和同意来证明重新招募家庭进入ECHO的可行性
(2)通过对成人医疗保健进行试点规模编码,为UH 3阶段做好准备;
记录,试点我们的地理编码系统,进行初步分析,并制定和测试一个简短的
社会环境逆境的措施;(3)与ECHO指导委员会合作和计划。在
在UH 3期间,我们将(1)通过加强我们对环境和
通过家庭和电话评估神经发育,肥胖,
气道功能和社会环境;以及(2)根据确定的情况开展ECHO联盟范围内的活动
ECHO指导委员会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jody M. Ganiban其他文献
Adolescent Social Media Use and Mental Health in the Environmental Influences on Child Health Outcomes Study
在儿童健康结果研究中的环境影响下青少年社交媒体使用与心理健康
- DOI:
10.1016/j.jadohealth.2024.12.003 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:4.500
- 作者:
Courtney K. Blackwell;Maxwell Mansolf;Theda Rose;Sarah Pila;David Cella;Alyssa Cohen;Leslie D. Leve;Monica McGrath;Jenae M. Neiderhiser;Audrey Urquhart;Jody M. Ganiban - 通讯作者:
Jody M. Ganiban
Children’s executive functioning and health behaviors across pediatric life stages and ecological contexts
- DOI:
10.1007/s10865-024-00543-w - 发表时间:
2025-01-09 - 期刊:
- 影响因子:2.900
- 作者:
Nichole R. Kelly;Derek Kosty;Yosef Bodovski;Courtney K. Blackwell;Jody M. Ganiban;Jenae M. Neiderhiser;Dana Dabelea;Diane Gilbert-Diamond;Judy L. Aschner;Theresa M. Bastain;Carrie V. Breton;Nicole R. Bush;Catrina A. Calub;Carlos A. Camargo;Marie Camerota;Lisa A. Croen;Amy J. Elliott;Michelle Bosquet Enlow;Assiamira Ferrara;Tina Hartert;Robert M. Joseph;Margaret R. Karagas;Rachel S. Kelly;Kristen Lyall;Kelsey E. Magee;Cindy T. McEvoy;Francheska M. Merced-Nieves;Thomas G. O’Connor;Sara Santarossa;Susan L. Schantz;Rebecca J. Schmidt;Joseph B. Stanford;Jennifer K. Straughen;Annemarie Stroustrup;Nicole M. Talge;Rosalind J. Wright;Qi Zhao;Leslie D. Leve - 通讯作者:
Leslie D. Leve
Jody M. Ganiban的其他文献
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{{ truncateString('Jody M. Ganiban', 18)}}的其他基金
The Early Growth and Development Study Pediatric Cohort
早期生长和发育研究儿科队列
- 批准号:
9267766 - 财政年份:2016
- 资助金额:
$ 295.57万 - 项目类别:
The Early Growth and Development Study Pediatric Cohort
早期生长和发育研究儿科队列
- 批准号:
9355711 - 财政年份:2016
- 资助金额:
$ 295.57万 - 项目类别:
The Early Growth and Development Study Pediatric Cohort
早期生长和发育研究儿科队列
- 批准号:
10205786 - 财政年份:2016
- 资助金额:
$ 295.57万 - 项目类别:
The Early Growth and Development Study Pediatric Cohort
早期生长和发育研究儿科队列
- 批准号:
10177315 - 财政年份:2016
- 资助金额:
$ 295.57万 - 项目类别:
The Early Growth and Development Study Pediatric Cohort
早期生长和发育研究儿科队列
- 批准号:
10240518 - 财政年份:2016
- 资助金额:
$ 295.57万 - 项目类别:
The Early Growth and Development Study Cohort of the ECHO Program
ECHO 项目的早期生长和发育研究队列
- 批准号:
10745202 - 财政年份:2016
- 资助金额:
$ 295.57万 - 项目类别:
Gene-Environment interplay and childhood obesity: An Adoption study.
基因-环境相互作用和儿童肥胖:一项收养研究。
- 批准号:
8186819 - 财政年份:2011
- 资助金额:
$ 295.57万 - 项目类别:
Gene-Environment interplay and childhood obesity: An Adoption study.
基因-环境相互作用和儿童肥胖:一项收养研究。
- 批准号:
8322011 - 财政年份:2011
- 资助金额:
$ 295.57万 - 项目类别:
Gene-Environment interplay and childhood obesity: An Adoption study.
基因-环境相互作用和儿童肥胖:一项收养研究。
- 批准号:
8477035 - 财政年份:2011
- 资助金额:
$ 295.57万 - 项目类别:
Gene-Environment interplay and childhood obesity: An Adoption study.
基因-环境相互作用和儿童肥胖:一项收养研究。
- 批准号:
8683162 - 财政年份:2011
- 资助金额:
$ 295.57万 - 项目类别:
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