The Early Growth and Development Study Pediatric Cohort

早期生长和发育研究儿科队列

• 批准号: 10240518
• 负责人: Jody M. Ganiban
• 金额: $ 295.57万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10240518
• 关键词: Address; Adolescence; Adopted; Adoption; Adult; Affect; Age; Area; Biological; Biological Factors; Biological Markers; Birth; Body mass index; Characteristics; Child; Child Health; Child Rearing; Childhood; Code; Cohort Studies; Collection; Consent; DNA; Data; Databases; Development; Diet; Disease; Documentation; Drug usage; Economics; Elements; Environment; Environmental Exposure; Environmental Impact; Environmental Risk Factor; Family; Family Study; Future; Genetic; Genetic Risk; Goals; Growth; Growth and Development function; Health; Heritability; Home; Household; Hydrocortisone; Infrastructure; Inherited; Lead; Life; Measurement; Measures; Medical Records; Mental Health; Methods; Modeling; Neighborhoods; Obesity; Outcome; Parents; Pediatric cohort; Phase; Play; Pregnancy; Prevention; Procedures; Process; Protocols documentation; Quantitative Genetics; Recording of previous events; Reporting; Research Infrastructure; Risk; Role; Salivary; Sampling; Sampling Studies; Siblings; Social Development; Social Environment; Specimen; System; Telephone; Testing; Update; Work; adopted child; cognitive development; cohort; design; early childhood; early life exposure; executive function; follow-up; genetic analysis; health disparity; improved; indexing; member; neurodevelopment; obesity risk; physical conditioning; postnatal; prenatal; prospective; psychiatric symptom; recruit; retention rate; social; socioeconomics; stressor

7. Project Summary/Abstract Increasing evidence suggests that exposures from pregnancy through age 5 can result in health deficits and lead to life-long consequences. We propose to leverage and build upon a unique existing “dual-family” adoption design to isolate early environmental exposures from heritable influences on familial clustering of health problems to contribute to ECHO's overall goal of investigating the role of early life exposures and underlying biological mechanisms in childhood health and disease. Our pediatric sample will be drawn from three cohorts of children (N = 1,201 children) who have been followed prospectively since birth in the Early Growth and Development Study (EGDS). The EGDS cohorts consist of two types of families: adoptive families in which the child is not genetically related to either rearing parent (n = 790 children), and biological families in which the child is genetically related to the rearing parent (n = 411 children). Within these families, we have n = 927 sibling pairs of two types: (1) siblings living apart, in which one sibling was adopted at birth and reared with genetically unrelated parents and the other sibling remained in the biological home and was reared by the biological parent from birth (n = 365 pairs), and (2) siblings living together either in the adoptive home or the biological home (n = 562 pairs). We have established a reliable research infrastructure, exceptional measurement of the early childhood family social environment, medical records data, DNA and salivary cortisol samples, high retention rates, and reliable and transparent data-sharing methods. We will use our well- established prospective adoption sample to (a) help clarify causal inferences about environmental influences on neurodevelopment and obesity, and (b) explore the unfolding interplay between inherited child characteristics and environmental influences from birth to adolescence. In cohorts in which children are reared by biological parents, it is difficult to differentiate the role of the social environment from that of genetic influences. Our dual-family design addresses this fundamental confound. In this application, we emphasize the Focus Area of Neurodevelopment; however, our sample and approach are also well suited for examining environmental influences on Obesity and Airways Focus Areas, as secondary and tertiary foci. In the UG3 phase, we will (1) demonstrate the feasibility of rerecruiting families into ECHO by rerecruiting and consenting families of 1,000 children; (2) prepare for the UH3 period by conducting pilot scale coding of adult medical records, piloting our geocoding system, conducting preliminary analyses, and developing and testing a brief measure of social environmental adversity; and (3) collaborate and plan with the ECHO Steering Committee. In the UH3 period, we will (1) build on the UG3 activities by enhancing our assessment of environmental and inherited risks in the EGDS cohort through in-home and phone assessments of neurodevelopment, obesity, airway function, and the social environment; and (2) conduct ECHO consortium-wide activities as determined by the ECHO Steering Committee.

7。项目摘要/摘要 越来越多的证据表明，从怀孕到5岁的暴露会导致健康不足，并且 导致终身后果。我们建议利用和建立独特的现有“双户家庭” 采用设计，以隔离早期环境暴露于对家庭聚类的影响 健康问题是为了促进Echo的总体目标，即调查早期生活的作用和 儿童健康和疾病中的生物学机制。我们的儿科样本将从 自早期出生以来就经过前瞻性跟踪的三个儿童（n = 1,201个儿童） 增长与发展研究（EGD）。 EGDS人群由两种类型的家庭组成：自适应家庭 儿童与抚养父母（n = 790个孩子）和生物家庭无关 孩子通常与饲养父母有关（n = 411个孩子）。在这些家庭中，我们有n = 927对两种类型的兄弟姐妹对：（1）兄弟姐妹分开，其中一个兄弟姐妹出生并养育 一般无关的父母，其他兄弟姐妹仍留在生物学之家中，并由 从出生开始的亲生父母（n = 365对），（2）兄弟姐妹一起生活在自适应家庭中或 生物家庭（n = 562对）。我们已经建立了可靠的研究基础设施 幼儿家庭社会环境，病历数据，DNA和唾液皮质醇的测量 样品，高保留率以及可靠且透明的数据共享方法。我们将利用我们的福祉 已建立的前瞻性采用样本（a）有助于确定有关环境影响的因果关系的推论 关于神经发育和肥胖，（b）探索继承的孩子之间的展开相互作用 从出生到青少年的特征和环境影响。在养育儿童的队列中 通过亲生父母，很难区分社会环境与通用环境的作用 影响。我们的双户设计设计解决了这一基本混杂。在此应用中，我们强调 神经发育的焦点区域；但是，我们的样本和方法也非常适合考试 环境对肥胖和气道重点区域的影响，如二级和三级焦点。在UG3中 阶段，我们将（1）通过重新获得和同意证明将家族重新养育为回声的可行性 1,000名儿童的家庭； （2）通过进行成人医学的试验量表为UH3时期做准备 记录，试用我们的地理编码系统，进行初步分析以及开发和测试简要介绍 衡量社会环境逆境； （3）与回声指导委员会合作和计划。在 UH3时期，我们（1）通过加强我们对环境和环境的评估来建立UG3活动 通过神经发育，肥胖， 气道功能和社会环境； （2）按确定 由回声指导委员会。