Columbia University/Aga Khan University Global Network Research Unit

项目摘要 阿加汗大学/哥伦比亚大学（AKU/CU）全球网络研究单位正在申请继续 全球妇女和儿童健康研究网络（Global Network for Women's and Children's Health Research，简称GN）。在 该项目位于社区卫生部内的妇产科和AKU 科学（CHS）。迄今为止，我们的网站一直是GN中最具生产力的网站之一。我们充分参与了 全球网络的各个方面，从开发成功的单站点和通用协议概念到领导能力 在GN委员会。我们已经获得了非GN资金，以支持GN多站点项目，并加强 在AKU的CHS部门。我们已经证明可以接触到大量的城市和农村人口，并成功地 进行了许多基于医院和社区的研究。我们为GN贡献了更多的集群 注册和随机分组试验的数量超过其他任何研究中心。我们的随访率和数据质量 好极了在GN的22年里，我们已经招募了近30万名妇女和儿童参加GN项目 发表了300多篇论文在接下来的7年里，我们计划继续或超过这一参与水平， 详细如下。作为GN的一部分，我们将对孕妇进行多中心干预试验， 在巴基斯坦和其他低资源国家，我们正在努力提高新生儿和儿童的健康水平，以降低他们的死亡率和发病率。我们 我明白，具体的项目将由一个独立的委员会选择，这些项目可能来自 来自GN研究者或GN以外的研究者。我们会继续以人口为基础， 巴基斯坦的怀孕及其结果登记，以衡量与这些怀孕及其结果有关的趋势和因素， 结果，并将风险因素和结果与其他GN站点进行比较。我们将继续成为领导者， GN研究中心在方案制定、受试者招募、数据质量和获得GN外部资金方面的能力 项目，并继续刺激巴基斯坦研究人员的发展，并促进 AKU的研究人员和来自CU和其他美国网站的研究人员。我们将继续吸引新的巴基斯坦和美国 通过对初级研究人员的系统指导， 从相关领域招募资深科学家，并继续改善AKU的研究环境， 以科学的方法，提供高质素的行政、财政、统计及研究支援服务。 激励多学科设置。我们还将继续支持政府努力加强 通过促进培训适合各国的新的具有成本效益的干预措施， 资源有限。由于我们的研究团队的许多优势及其致力于改善 在资源匮乏的环境中妇女和儿童的健康，以及其在全球网络内的长期合作历史 与巴基斯坦的许多实体一起，我们坚信上述目标将几乎实现 立即并无限期地继续，AKU/CU站点将继续成为GN的领导者。

Project Summary The Aga Khan University/Columbia University (AKU/CU) Global Network Research Unit is applying to continue its membership in the Global Network for Women's and Children's Health Research (Global Network [GN]). At CU, the project is located in the Department of OBGYN and at AKU within the Department of Community Health Sciences (CHS). To date, our site has been among the most productive in the GN. We have fully participated in all aspects of the GN from developing successful concepts for single site and common protocols to leadership on GN committees. We have acquired non-GN funds both to support GN multisite projects and to strengthen the Department of CHS at AKU. We have proven access to large urban and rural populations and have successfully performed many hospital-based and community-based studies. We have contributed more clusters to the GN Registry and cluster-randomized trials than any other site. Our follow-up rates and the quality of our data are excellent. Over the 22 years in the GN, we have enrolled nearly 300,000 women and children into GN projects and authored over 300 papers. In the next 7 years, we plan to continue or surpass this level of engagement as detailed below. As part of the GN, we will conduct multi-center trials of interventions for pregnant women, newborns and children to reduce their mortality and morbidity in Pakistan and other low-resource countries. We understand that the specific projects will be chosen by a stand-alone committee and these could originate either from a GN investigator or an investigator from outside the GN. We will continue to maintain a population-based registry of pregnancies and their outcomes in Pakistan, to measure trends and factors associated with those outcomes and to compare risk factors and outcomes to other GN sites. We will continue being a leader among the GN sites in protocol development, subject recruitment, data quality and obtaining outside funding for GN projects and continue to stimulate the development of Pakistani researchers and promote collaborations between AKU researchers and those from CU and other US sites. We will continue to attract new Pakistani and US investigators to global maternal and child health research by systematic mentoring of junior investigators and recruiting senior scientists from related fields, and to continue enhancing the research environment at AKU by providing high-quality administrative, financial, statistical and research support services within a scientifically stimulating multidisciplinary setting. We also will continue to support government endeavors to strengthen the health system in our research site by facilitating training on new cost-effective interventions suitable for countries with limited resources. Because of the many strengths of our research team and its dedication to improving the health of women and children in low-resource settings, as well as its long history of collaboration within the GN and with many entities in Pakistan, we strongly believe that the goals described above will be achieved almost immediately and continue indefinitely, and that the AKU/CU site will continue to be a leader in the GN.