CSHL 2023 Mechanisms of Metabolic Signaling Conference

冷泉港实验室会议 代谢信号转导机制 2023年5月16日至20日 项目摘要 这项提议寻求支持关于“代谢信号传递机制”的会议 于2023年5月16日至20日在冷泉港实验室举行。这次会议将召集各国领导人 在现场，与初级教师、博士后研究员和研究生一起讨论 代谢调节及其在正常生理中作用的最新研究进展 以及从肥胖到癌症的各种疾病状态。 新陈代谢过程是生命所必需的，而且从一个生物体到另一个生物体都非常相似 从一个细胞到另一个细胞。在哺乳动物中，特定类型的细胞使用高度专门化的代谢途径 执行其特定细胞功能的方法。此外，某些细胞类型的特殊功能 用来维持多细胞生物体的代谢动态平衡 血液中的荷尔蒙和代谢物信使。肥胖等代谢性疾病 当这些过程失败时，就会导致糖尿病。与此同时，癌症也日益增多。 被认为是一种恶性细胞通过改变其燃料代谢而增殖的状态 忽视新陈代谢信号。 会议将涉及广泛的话题，从代谢与基因组的串扰 和表观基因组对器官间串扰和养分利用的影响。此外，还有一节课是 致力于该领域的新兴技术。每期会议将由一位主要负责人主持 这一领域的科学家。口头陈述将由一群杰出的特邀演讲者进行 以及从提交的摘要中挑选的发言者。选定的演讲者将包括毕业生 学生、博士后研究员和初级教职员工的目标是最大限度地包容年轻人 调查人员。特别重要的是两个海报会议，在那里许多参与者可以 在有利于非正式讨论的气氛中介绍他们的工作。会议将于 中等规模，我们预计将有大约250人参加，其中绝大多数将是 展示海报或演讲。会议主席和演讲者将被要求亲自出席 确保足够多的与会者聚集在冷泉港；然而，我们将促进 在面对面出席的基础上增加了虚拟观众。这一点对双方都很重要 因为在大流行后，对旅行的担忧可能会持续一段时间，而且因为， 展望未来，虚拟出席会议将有助于减少科学研究的影响 关于气候变化的会议，并使世界各地的实验室能够更公平地参与 世界。

Cold Spring Harbor Laboratory Conference on Mechanisms of Metabolic Signaling May 16 – 20, 2023 Project Summary This proposal seeks support for the meeting on “Mechanisms of Metabolic Signaling” to be held at Cold Spring Harbor Laboratory in May 16 - 20, 2023. The meeting will assemble leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to discuss the latest advances in our understanding of metabolic regulation and its role in normal physiology as well as a variety of disease states ranging from obesity to cancer. Metabolic processes are required for life, and are remarkably similar from organism to organism and from cell to cell. In mammals, specific cell types use metabolic pathways in highly specialized ways to conduct their cell-specific functions. Further, the specialized function of some cell types serves to maintain metabolic homeostasis of the, multicellular organism by regulating levels of hormone and metabolite messengers in the bloodstream. Metabolic diseases such as obesity and diabetes result when those processes fail. At the same time, cancer is increasingly recognized as a state whereby the malignant cell proliferates by altering its fuel metabolism and ignoring metabolic signals. The meeting will cover a broad spectrum of topics ranging from Metabolic Crosstalk with Genome and Epigenome to Interorgan Crosstalk and Nutrient Utilization. In addition, one session is dedicated to Emerging Technologies in the field. Each session will be chaired by a leading scientist in the field. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size, and we expect about 250 people to attend, the vast majority of whom will be presenting a poster or talk. Session chairs and presenters will be required to attend in-person to ensure a critical mass of attendees gathering at Cold Spring Harbor; however, we will facilitate an additional virtual audience layered on top of the in person attendance. This will be important both because travel concerns are likely to persist for some time after the pandemic, and because, looking to the future, virtual attendance at meetings will help to reduce the effects of scientific conferences on climate change and enable more equitable participation from labs around the world.