Characteristics of COVID-19 in transgender people

项目总结/摘要 跨性别人士可能会受到2019冠状病毒感染疾病（COVID-19）的影响 这是因为她们可能面临获得及时护理的障碍， HT对COVID-19疾病严重程度的影响。基于这些考虑，拟议的总体目标 行政补充将收集和分析更多数据，以描述COVID-19疫情 在不同亚组的STRONG队列成员相对于匹配的顺性对照。 拟议的行政补充将包括为正在进行的母项目收集更多数据 “跨性别人群的扩展国家队列研究”（R 01 AG 066956）。五年的母项目， 这是第二年，代表了以前建立的过渡研究的扩展， 结果和性别（强）。STRONG是一群在Kaiser Permanente注册的变性人 (KP)格鲁吉亚、北方加州、南方加州和大西洋中部的综合医疗保健计划 States.扩大后的队列包括大约40，000名变性人与800，000名男性相匹配 和女性的顺性别参照物我们将使用更多的STRONG数据来比较COVID的发病率和类型- 19在跨男性（TM）和跨女性（TF）的人顺性别对照接种疫苗，检查 变性人和顺性人之间的疾病发病率，并调查是否变性状态， 接受激素治疗和激素水平在COVID-19的严重程度中发挥作用。的独特特征 建议的分析是，它既考虑了性别的生物变量，也考虑了社会，环境， 定义性别的文化和行为因素-在跨NIH战略中明确概述的区别 计划 1

PROJECT SUMMARY/ABSTRACT Transgender people may be disproportionally affected by the coronavirus infection disease 2019 (COVID-19) pandemic because they may face barriers to timely care and because of the possible effect of gender-affirming HT on COVID-19 disease severity. Based on these considerations, the overall goal of the proposed administrative supplement will be to collect and analyze additional data to characterize the COVID-19 epidemic in different subgroups of STRONG cohort members relative to matched cisgender controls. The proposed administrative supplement will include additional data collection for the ongoing parent project “An expanded national cohort study of transgender people” (R01AG066956). The five-year parent project, which is now in its second year, represents an expansion of the previously established Study of Transition, Outcomes and Gender (STRONG). STRONG is a cohort of transgender people enrolled in Kaiser Permanente (KP) integrated health care plans in Georgia, Northern California, Southern California, and the Mid-Atlantic States. The expanded cohort includes approximately 40,000 transgender persons matched with 800,000 male and female cisgender referents. We will use additional STRONG data to compare rates and types of COVID- 19 vaccination in transmasculine (TM) and transfeminine (TF) persons to cisgender controls, examine the incidence of the disease among transgender and cisgender individuals and investigate if transgender status, receipt of hormone therapy, and levels of hormones, play a role in COVID-19 severity. A unique feature of the proposed analysis is that it considers both the biological variable of sex as well as the social, environmental, cultural, and behavioral factors that define gender – a distinction clearly outlined in the Trans-NIH Strategic Plan. 1