Stroke, Cognition and Neuroepidemiology Section
Stroke, Cognition and Neuroepidemiology Section
批准号:
10916014
负责人:
Rebecca F Gottesman
金额:
$230.6万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Atherosclerosis Risk in CommunitiesBlood VesselsBrain hemorrhageCADASILCerebral small vessel diseaseCerebrovascular DisordersClinical ProtocolsCognitionCognitiveCollaborationsComplementDementiaDiseaseDisparityEtiologyEvaluationExtramural ActivitiesFundingFutureGeneral PopulationGenesGoalsHealthHemorrhageHigh PrevalenceHumanImpaired cognitionIndividualInfarctionInheritedInterventionIntramural Research ProgramIschemic StrokeLife Cycle StagesMeasurementMethodsMicrovascular DysfunctionNational Institute of Neurological Disorders and StrokeNeuroepidemiologyPathway interactionsPatternPopulation StudyPreventionRecoveryRecurrenceRiskRisk FactorsRoleStrokeUnited States National Institutes of HealthVascular Diseasesblood-based biomarkerbrain healthcognitive changecognitive performancecohortdisparity reductionepidemiology studyexperienceimaging biomarkermiddle agemodifiable riskneuroimagingpost strokepost stroke cognitive impairmentsocial health determinantsvascular cognitive impairment and dementiavascular risk factor
中文摘要
血管危险因素与认知能力下降和痴呆有关,尤其是在中年评估时。这些相同的危险因素是否决定中风后认知障碍的风险尚不清楚,中风后血管风险普遍升高,其他可改变的危险因素的作用也不清楚。此外,血管影响认知的机制是否仅通过可识别的脑血管疾病成像标志物(如小血管疾病、无症状性梗死或微出血),或者是否存在血管风险导致认知障碍的其他机制,目前尚不清楚。扫描部分正在进行的研究评估了与VCID存在,病因和潜在预防途径相关的问题。
英文摘要
Vascular risk factors are associated with cognitive decline and dementia, especially when evaluated in middle age. Whether these same risk factors determine risk of cognitive impairment after stroke, a condition where vascular risk is generally elevated, is not clear, nor is the role of other modifiable risk factors. Furthermore, whether the mechanism of a vascular impact on cognition is solely via identifiable imaging markers of cerebrovascular disease (such as small vessel disease, silent infarcts or microbleeds) or whether there are other mechanisms by which vascular risk contributes to cognitive impairment is not well understood. Ongoing studies in the SCAN section evaluate related questions to VCID presence, etiology, and potential pathways for prevention.
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DOI:
10.3389/fneur.2022.766305
发表时间:
2022
期刊:
Frontiers in neurology
影响因子:
3.4
作者:
[Bahouth MN, Saylor D, Hillis AE, Gottesman RF]
通讯作者:
Gottesman RF
Guy McKhann, First Head of Hopkins' Department of Neurology.
盖伊·麦克卡恩 (Guy McKhann),霍普金斯大学神经内科第一任主任。
DOI:
--
发表时间:
2023
期刊:
Annals of neurology
影响因子:
11.2
作者:
[McArthur,JustinC, Gottesman,RebeccaF]
通讯作者:
Gottesman,RebeccaF
DOI:
10.1016/j.bpsgos.2022.04.005
发表时间:
2023-07
期刊:
Biological psychiatry global open science
影响因子:
--
作者:
[]
通讯作者:
Looking for opportunities to co-enroll: The DISCOVERY study experience.
寻找共同注册的机会:DISCOVERY 学习体验。
DOI:
10.1016/j.jstrokecerebrovasdis.2022.106862
发表时间:
2022
期刊:
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子:
--
作者:
[Anisetti,Bhrugun, Rost,Natalia, Barrett,Kevin, Gottesman,Rebecca, Graff-Radford,Jonathan, Kittner,Steven, Boden-Albala,Bernadette, Cissel,Heather, Mills,Brittany, Carman,Kaley, Vemuri,Prashanthi, Wruck,Lisa, Bhapkar,Manjushri, Donahue,Katy, ]
通讯作者:
DOI:
10.3389/fneur.2022.1028296
发表时间:
2022
期刊:
Frontiers in neurology
影响因子:
3.4
作者:
[]
通讯作者:
共 8 条
DISCOVERY - Statistics and Analysis Core
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批准号:10021041
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项目类别:
-
资助金额:$64.23万
-
财政年份:2019
-
负责人:Rebecca F Gottesman
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依托单位:
DISCOVERY - Statistics and Analysis Core
-
批准号:10241403
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项目类别:
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资助金额:$64.23万
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财政年份:2019
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负责人:Rebecca F Gottesman
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依托单位:
DISCOVERY - Statistics and Analysis Core
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批准号:10709865
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项目类别:
-
资助金额:$151.04万
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财政年份:2019
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负责人:Rebecca F Gottesman
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依托单位:
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's disease
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批准号:9323230
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项目类别:
-
资助金额:$16.05万
-
财政年份:2016
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负责人:Rebecca F Gottesman
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依托单位:
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's disease
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批准号:9922187
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项目类别:
-
资助金额:$16.05万
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财政年份:2016
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负责人:Rebecca F Gottesman
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依托单位:
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's disease
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批准号:9086843
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项目类别:
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资助金额:$16.05万
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财政年份:2016
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:8162024
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资助金额:$59.1万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:9477412
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项目类别:
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资助金额:$71.61万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:8726266
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项目类别:
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资助金额:$55.99万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:8545376
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项目类别:
-
资助金额:$94.95万
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财政年份:2011
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负责人:Rebecca F Gottesman
-
依托单位:
The ARIC-PET Amyloid Imaging Study
-
批准号:8885622
-
项目类别:
-
资助金额:$50.82万
-
财政年份:2011
-
负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
-
批准号:9185481
-
项目类别:
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资助金额:$76.17万
-
财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
-
批准号:8495842
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项目类别:
-
资助金额:$53.41万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
-
批准号:8328639
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项目类别:
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资助金额:$56.96万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
-
批准号:9925759
-
项目类别:
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资助金额:$68.38万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
-
批准号:9346656
-
项目类别:
-
资助金额:$72.37万
-
财政年份:2011
-
负责人:Rebecca F Gottesman
-
依托单位:
Stroke, Cognition and Neuroepidemiology Section
-
批准号:10708648
-
项目类别:
-
资助金额:$138.98万
-
财政年份:--
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负责人:Rebecca F Gottesman
-
依托单位:
DISCOVERY - Statistics and Analysis Core
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批准号:9918028
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项目类别:
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资助金额:$77.42万
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财政年份:--
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负责人:Rebecca F Gottesman
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依托单位:
海外基金