Environmental influences on Child Health Outcomes in the Northern Plains PASS-ECHO Cohort

项目摘要 该提案旨在利用安全通道研究ECHO（PASS ECHO）研究基础设施，该基础设施已招募了一名 ECHO母亲/儿童对的大队列（n=6.647）继续随访，以及继续招募新的 怀孕和启动孕前队列。PASS ECHO研究团队从2016年到2023年的成功，无论是在 科学协作，完成作战任务，为增加招生提供良好基础 和保留ECHO参与者，包括大部分农村和美洲印第安人参与者。通过回声 专门研究ECHO肥胖症健康结果。以下具体目标直接关系到促进 协同ECHO队列科学，完成与成功参与下一阶段相关的操作任务 的ECHO。(SA1)检查产前非稳态负荷及其生物标志物对儿童肥胖的影响， 神经发育(SA2)检查产前生活方式相关暴露对儿童的独立和联合影响 肥胖相关的结果，以及营养如何影响这些关系。(SA3)基于已证明的成功 战略和强大的社区/参与者关系，以实施ECHO范围内的协议v3.0， 努力增加美国印第安人和农村社区的参与。

PROJECT SUMMARY This proposal serves to leverage the Safe Passage Study ECHO (PASS ECHO) research infrastructure that has recruited a large cohort of ECHO mother/child pairs (n=6.647) for continued follow-up, as well as continued enrollment of new pregnancies and initiating a preconception cohort. The success of the PASS ECHO research team from 2016-2023, both in scientific collaboration and completing of operational tasks, provides an excellent foundation for increased enrollment and retention of ECHO participants, including a large proportion of rural and American Indian participants. PASS ECHO has a specialization in the ECHO Obesity health outcome. The following specific aims relate directly to advancing collaborative ECHO Cohort science and completing operational tasks relevant for successful participation in the next phase of ECHO. (SA1) Examine the effects of prenatal allostatic load, and its biomarkers, on childhood obesity and neurodevelopment. (SA2) Examine the independent and joint effects of prenatal life-style related exposures on child obesity-related outcomes, and how nutrition may impact these relationships. (SA3) Build upon demonstrated successful strategies and strong community/participant relationships to implement the ECHO-wide protocol v3.0 with deliberate efforts to increase participation in American Indian and rural communities.