A formal group theory-based model in primates for studying interactive social behavior and its dysfunction

基于形式群论的灵长类互动社会研究模型 行为及其功能障碍 与通过动物模型广泛研究的大多数形式的孤独行为不同，非常少 已知交互社会行为及其功能障碍的单神经元或因果基础。其中一个 造成这种限制的主要原因是普遍缺乏研究神经的动物模型和框架。 社会行为的基础，两个或多个人通过这种方式实时互动 适用于神经元分析或微扰技术。这种有限的理解不仅影响广泛 跨越生态学、神经学和心理学等研究领域，也包括我们治疗疾病的能力 作为自闭症谱系障碍，其社会行为受到显著影响。灵长类动物具有高度的社会性 动物与人类有许多共同的行为，可以作为潜在的模型 了解互动行为背后的基本要素。在这项提案中，我们的目标是在我们的基础上 团队与共同互动的灵长类配对和群体、社会理论、多地点的独特组合体验 神经元记录和时间分辨神经调制技术开始识别一些基本的 交互行为的神经元编码成分及其在皮质内和跨皮质的表现 人口数量及其在短时间和长时间尺度上的动态。社会群体理论在灵长类动物中的应用 结合人口建模和扰动技术，我们将研究核心的社会结构，如 作为机构身份、群体动力和决策策略，对有效的社会行为至关重要。我们还将 测试关于不同的额叶、颞叶和顶叶区域在社交中的因果贡献的具体假设 互动以及具体涉及哪些方面。综上所述，这项提议旨在提供一个正式的理论- 基于模型，用来开始研究单个神经元、群体和 基于线路的标高。我们认为，这是一条重要的新调查路线，有可能开启 在神经科学中一个探索不足但很重要的领域，并从这个领域开始测试神经调节 旨在治疗心理社会障碍的干预措施。

A formal group theory-based model in primates for studying interactive social behavior and its dysfunction Unlike most forms of solitary behavior that have been broadly studied through animal models, remarkably little is known about the single-neuronal or causal bases of interactive social behavior and its dysfunction. One of the major reasons for this limitation is the general lack of animal models and framework for studying the neural substrates of social behavior whereby two or more individuals interact in real-time and in a way that is amenable to neuronal analysis or perturbation techniques. This limited understanding impacts not only wide spanning fields of study such as ecology, neurology and psychology but also our ability to treat conditions such as autism-spectrum disorder in which social behavior is prominently affected. Primates are highly social animals that share many behaviors in common with humans and can serve as a potential model for understanding the basic elements that underlie interactive behavior. In this proposal, we aim to build on our team’s unique combined experience with jointly interacting primate pairs and groups, social theory, multi-site neuronal recordings and time-resolved neuromodulation techniques to begin identifying some of the basic neuronal encoding components of interactive behaviors, their representation within and across cortical populations, and their dynamic across short and long temporal scales. Using social group theory in primates together with population modeling and perturbation techniques, we will investigate core social constructs such as agency identity, group dynamics and decision strategies essential for effective social behavior. We will also test specific hypotheses on the causal contribution that distinct frontal, temporal and parietal areas play in social interaction and what exact aspects are involved. Taken together, this proposal aims to provide a formal theory- based model by which to begin investigating interactive social behavior at the single-neuronal, population and circuit-based levels. We believe that this is an essential new line of investigation and has the potential to open up a poorly explored but important field within neuroscience and from which to begin testing neuro-modulatory interventions aimed at treating psychosocial disorders.