Admin-Core-001

项目概要/摘要：管理核心的使命是确保各个研究项目和研究核心在其各自部分之外协同联合收割机，为TBEL计划做出贡献，从而在各个中心之外创造力量，与NCI和癌症研究界整合。行政核心为这一使命提供了必不可少的基础设施。核心将监督一个多组成部分的研究计划，包括两个基础科学和一个翻译项目，并利用不同的数据收集和分析模式。为了促进协同作用，核心将是内部活动的主要联系人，包括后勤和组织活动、科学和行政活动以及合作项目征集、审查、资助和评估。为了将我们拟议的中心嵌入TBEL计划和更广泛的癌症研究社区，该核心也将是与NCI，其他TBEL中心，协调和数据管理中心（CDMC）和外部癌症研究人员进行外部互动的主要联系人。核心领导人De Marzo和Yegnasubramanian博士19年来一直是积极的合作者，在过去的6年里，他们共同资助了NCI SPORE赠款和NCI MCL赠款，并共同撰写了50篇同行评审的主要出版物和16篇评论文章。De Marzo博士和Yegnasubramanian博士还参与了支持其角色的内部和外部研究网络。此外，他们还共同指导了几名研究生和博士后研究员，经常在他们的研究生论文委员会任职。在过去的10年里，他们在前列腺癌的分子病理学和基因组学方面进行了广泛的合作，包括领导JHU NCI MCL-U 01项目的所有RNAseq和全基因组测序工作，包括临床前图谱试点。此外，他们一起广泛研究了前列腺前体病变的分子和细胞生物学，共同发现了高级别PIN病变和PIA中GSTP 1的部分DNA甲基化;这一发现与当前的提议直接相关。最后，他们与Bieberich博士在前列腺炎症驱动的肿瘤和侵袭性与惰性前列腺癌的小鼠模型的分子病理学和基因组学方面进行了广泛的合作，并与Pienta博士在与NCI MCL-U 01计划相关的所有管理方面和肿瘤微环境研究中进行了广泛的合作。

Project Summary/Abstract: The mission of the Administration Core is to ensure that the individual Research Projects, and the Research Core combine with synergy beyond their individual parts, to contribute to the TBEL Program creating strength beyond the individual Centers, to integrate with the NCI and the cancer research community. The Administrative Core provides the infrastructure essential for this mission. The Core will supervise a multi-component research program encompassing two basic science and one translational projects, and utilizing diverse data collection and analysis modalities. To foster synergy, the Core will be the primary contact for internal activities including logistical and organizational activities, scientific and administrative activities, and collaborative project solicitation, review, funding, and evaluation. To embed our proposed Center within the TBEL Program and the broader cancer research community, this Core will also be the primary contact for external interactions with the NCI, other TBEL Centers, the Coordinating and Data Management Center (CDMC), and external cancer researchers. The Core Leaders, Drs. De Marzo and Yegnasubramanian, have been active collaborators for 19 years, have joint funding on the NCI SPORE grant as well as the NCI MCL grant for the past 6 years and are co-authors on 50 peer-reviewed primary publications and 16 review articles. Drs. De Marzo and Yegnasubramanian are also embedded in internal and external research networks that support their roles. In addition, they have co-mentored several graduate students and post-doctoral fellows, often serving on their fellow graduate student's thesis committees. They have worked together extensively on the molecular pathology and genomics of prostate cancer over the last 10 years, including leading all the RNAseq and whole genomic sequencing efforts for JHU the NCI MCL-U01 projects, including the pre-clinical atlas pilot. Also, together they have worked extensively on the molecular and cellular biology of prostate precursor lesions , together finding partial DNA methylation of GSTP1 in high grade PIN lesions and PIA; a finding directly relevant to the current proposal. Finally, they have worked together extensively, with Dr. Bieberich, on the molecular pathology and genomics of mouse models of prostatic inflammation driven neoplasia and of aggressive versus indolent prostate cancer, and with Dr. Pienta in all administrative aspects and tumor microenvironment studies related to the NCI MCL-U01 Program.