HCHS-SOL AE FIELD CENTER DIVERSITY SUPPLEMENT FOR DR. TREJO

HCHS基线研究的主要目标是检查西班牙裔/拉丁裔的患病率和疾病发展，文化适应的作用，并确定在西班牙裔/拉丁裔中发挥保护或有害作用的风险因素。该项目将利用HCHS数据来检查西班牙裔/拉丁裔人群中疑似非酒精性脂肪肝的遗传风险，并检查遗传血统的差异。它将扩展先前HCHS在肝病遗传学领域的工作，同时做出多队列池项目的新贡献，以增强统计能力和增加研究结果的普遍性。Trejo博士对这一补充申请的具体研究活动将包括进行数据分析，使用来自父母研究的数据准备手稿，以及基因数据管理

The primary goals for the HCHS baseline study are to examine the prevalence and development of disease in Hispanics/Latinos, the role of acculturation, and to identify risk factors that play protective or harmful roles in Hispanics/Latinos. This project will leverage the HCHS data to examine the genetic risk of suspected nonalcoholic fatty liver disease in Hispanic/Latino populations and to examine differences by genetic ancestry. It will expands on previous HCHS work in the area of the genetics of liver disease, while making the novel contribution of a multicohort pooling project to enhance statistical power and increase generalizability of findings. Dr. Trejo's specific research activities for this supplemental application will involve conducting data analyses, manuscript preparation using data available from the parent study, and genetic data management and analysis that will expand on his previous work.