BOVINE IGG AND INFANT COLIC

婴儿绞痛是一种病因不明的儿科疾病。绞痛是 以过度哭闹为特征，影响了20%的美国婴儿， 无论是母乳喂养还是配方奶喂养。绞痛很重要，因为婴儿 痛苦，父母因痛苦的哭泣而沮丧，一些虐待婴儿 死亡率、儿科医生的努力、费用和缺乏有效的治疗。 由于婴儿配方奶粉和母乳中的牛免疫球蛋白(BGG)水平是 可比性是，母乳血糖水平似乎与绞痛有关， 饮食血糖是否可能是绞痛的主要原因的调查 是提议的。BGG是人类饮食中主要的外来免疫球蛋白 (通常为500毫克/天)，并具有有意运输的独特性质， 稳定性、与Fc受体的结合和免疫调节。离体 研究表明，BGG可能对发育中的粘膜产生深远的影响 并可能引发绞痛和某些炎症性疾病。 作为一个直接的目标，这一假设将直接通过 对婴儿进行双盲安慰剂对照试验 服用BGG和安慰剂后的反应。两个母乳喂养的婴儿 配方奶粉喂养的婴儿将接受检测，绞痛反应将是 用简化的哭日记进行评估。母性消费的影响 乳制品对母乳中血糖和绞痛水平的影响 婴儿也将被研究。由于初步数据显示 不同类型结肠炎患者的血清BGG水平 目的是确定BGG是否在乳汁诱导中发挥重要作用 结肠炎、溃疡性结肠炎和嗜酸性胃肠炎。这将是 可通过分析急性加重期患者的血清来实现 这些BGG水平的紊乱将通过RAST法进行评估。 另一个目标是更好地了解BGG是如何选择性地运输的 以及BGG如何在易感人群中导致绞痛或其他疾病。 肠道FCR是否会对BGG的选择性吸收起作用 在使用FCR缺陷小鼠品系的动物模型中进行研究。方式和方式 当选择性BGG运输发生时，我将对人类进行调查 测定妊娠不同阶段的乳汁和血清BGG水平 哺乳。了解摄入的牛免疫球蛋白在绞痛和腹痛中的作用 其他疾病可能会带来更好的预防和治疗方法。 这项研究也可能为自身免疫的病因学提供见解。 疾病(类风湿性关节炎、I型糖尿病)。

Infant colic is a pediatric disorder of unknown etiology. Colic is characterized by excessive crying and it affects 20% of U.S. infants, whether breast-fed or formula-fed. Colic is important because of infant pain, parental frustration with inconsolable crying, some infant abuse mortality, pediatrician effort, expense, and lack of effective treatment. Since levels of bovine IgG (BGG) in infant formulas and human milk are comparable, and breast milk BGG levels seems to correlated with colic, an investigation of whether dietary BGG might be a major cause of colic is proposed. BGG is the major foreign immunoglobulin in the human diet (often 500 mg/day) and has unique properties of intentional transport, stability, binding to Fc receptors, and immunomodulation. In vitro studies suggest that BGG may profoundly influence the developing mucosal immune system and might initiate colic and certain inflammatory diseases. As one immediate goal, this hypothesis will be tested directly by conducting double-blind placebo-controlled trials comparing infant responses after ingestion of BGG and placebo. Both breast-fed infants and formula-fed infants will be tested and colic responses will be assessed by simplified cry diaries. The effect of maternal consumption of diary products on breast milk levels of BGG and on colic in breast-fed infants will also be studied. Since preliminary data show elevated levels of serum BGG in patients with various forms of colitis, a second goal is to determine whether BGG plays an important role in milk-induced colitis, ulcerative colitis, and eosinophilic gastroenteritis. This will be carried out by analyzing sera of patients during exacerbations of these disorders for levels of BGG will be assessed by RAST assay. Another goal is to better understand how BGG is selectively transported and how BGG may cause colic or other diseases in susceptible individuals. Whether intestinal FcR account for selective BGG absorption will be studied in an animal model using a FcR-deficient mouse strain. How and when selective BGG transport occurs i humans will be investigated by measuring milk and serum levels of BGG at various stages of pregnancy and lactation. A knowledge of the role of ingested bovine IgG in colic and other disorders may lead to better methods of prevention and treatment. This research might also provide insights into etiology of autoimmune diseases (rheumatoid arthritis, Type I diabetes).