Hematopathology Diagnosis

Pittaluga博士和我协助诊断和分类反应性和肿瘤性淋巴增生性疾病、免疫缺陷状态和各种血液恶性肿瘤。我们为NCI的医生以及其他机构（特别是NIAID、NHLBI、NHGRI和NIAMSD）研究血淋巴疾病患者的医生提供咨询和协作服务。我们定期出席由NCI临床分支和其他研究所（NIAID、NHLBI和NHGRI）主办的会议。我们每年会诊超过2000宗个案。我们尽量将会诊限制在困难或有挑战性的病例，不接受“常规第二意见”的病例。相当大比例（约20%）的病例是由其他学术机构提交的，原因是诊断不确定，或由于几个机构之间的意见分歧。我们经常是具有挑战性的诊断问题的最终仲裁者。此外，我们在临床实践的基础上进行了新的观察，并发表了一些出版物，这些出版物来自最初在咨询中审查的病例材料。我们的临床咨询实践也与其他NIH临床小组协同，加强NIH临床协议的转诊。我们的工作改善了几种罕见疾病的诊断和分类，包括多中心Castleman病，KSHV和ebv相关的增殖，新型b细胞和t细胞淋巴瘤，扩大了组织细胞肿瘤的范围。我们已经帮助确定了发生在成人和儿童年龄组的淋巴瘤之间的差异。我们研究了淋巴结淋巴瘤和结外淋巴瘤的区别。这项工作提高了我们对淋巴细胞和组织细胞肿瘤分类的认识。

Dr. Pittaluga and I aid in the diagnosis and classification of reactive and neoplastic lymphoproliferative disorders, immunodeficiency states, and diverse hematological malignancies. We provide consultative and collaborative services to physicians in the NCI, as well as to physicians studying patients with hematolymphoid disorders in other institutes, in particular NIAID, NHLBI, NHGRI, and NIAMSD. We regularly present at conferences sponsored by clinical branches in the NCI and other Institutes (NIAID, NHLBI, and NHGRI.) We receive more than 2000 cases in consultation each year. We try to restrict consultations to difficult or challenging cases, and do not accept cases for "routine second opinions". A significant proportion (approximately 20%) of the cases are submitted by other academic institutions based on diagnostic uncertainty, or because of differences of opinion among several institutions. We are often the final arbiter on challenging diagnostic problems. Additionally, we have made novel observations based on our clinical practice, and a number of publications have emanated from case material originally reviewed in consultation. Our clinical consultation practice also synergizes with other NIH clinical groups, enhancing referral to NIH clinical protocols. Our work has led to improvement in the diagnosis and classification of several rare diseases including multicentric Castleman disease, KSHV- and EBV-associated proliferations, novel forms of both B-cell and T-cell lymphoma, and expanding spectrum of histiocytic neoplasms. We have helped to define the differences between lymphomas occurring in adults from those in the pediatric age group. We have studied the difference between nodal and extranodal lymphomas. This work has advanced our knowledge regarding the classification of lymphoid and histiocytic neoplasms.