Strengthening behavioral and social science research capacity to address the evolving challenges in HIV care and prevention in Uganda

项目总结： 抗逆转录病毒疗法(ART)的有效性和可获得性的增加导致了更长的时间， 为艾滋病毒携带者提供更健康、更有成效的生活。然而，这一成功呈现出 艾滋病毒携带者人口增长带来的意想不到的后果。艾滋病毒携带者面临的老龄化挑战 包括高风险共病、与衰老和艾滋病毒有关的跨部门耻辱的双重负担， 以及加速的老化过程。先前的研究表明，年龄较大的PLHIV更有可能是 与世隔绝。艾滋病毒相关耻辱和年龄歧视的交集是一个复杂的问题，需要进一步 实施减少污名干预措施的设计和可行性研究。还有一个 迫切需要进行研究，以解决我们对老龄化对健康的影响的认识上的严重差距 艾滋病毒/艾滋病和艾滋病毒/艾滋病加速老化过程的性质。因此，有必要培训 下一代研究人员来应对这些挑战并设计、实施和纵向扩展 针对乌干达和类似地区日益增长的老年艾滋病毒感染者的量身定做和针对具体情况的干预措施 资源受限设置。 在过去的4年里，我们在Makerere建立了一个全面的研究-培训计划 大学(MAK)，强调加强在行为和社会方面的领导力和专业知识 科学研究(BSSR-D43TW011304)，以应对艾滋病毒护理和预防方面不断变化的挑战 在乌干达。我们建立在麦晋桁教员与 加州大学旧金山分校(UCSF)，为跨学科提供合适的环境 在BSSR方面的培训。我们建议继续该计划，并将重点放在明年和续签申请上，以 应对艾滋病毒和老龄化的挑战。我们提出了一项为期一年的补助金，以激发人们对研究的兴趣 关于艾滋病毒和老龄化，并获得初步数据，以便为今后在这一领域的长期研究培训提供信息。 具体地说，我们的目标是：1)扩大MakBSSR培训方案，将艾滋病毒和艾滋病研究培训包括在内 老龄化、年龄歧视和交叉耻辱，2)为硕士和 博士后奖学金学员，以应对乌干达艾滋病毒和老龄化的不断变化的挑战，以及，3) 准备更新MakBSSR研究培训方案的申请，重点是艾滋病毒老龄化， 年龄歧视和跨界别的耻辱。本附录将利用MakBSSR的现有资源 计划包括在Mak的社会、行为和生物医学科学家之间的合作，合作 艾滋病项目，以及美国的合作大学。在为期一年的补习期内，我们计划培训一名 硕士研究生和两名博士后奖学金实习生，都在Mak。

Project summary: The effectiveness of and increased access to antiretroviral therapy (ART) has resulted in longer, healthier, and more productive lives for people living with HIV (PLHIV). However, this success presents unexpected consequences of a growing population of people aging with HIV. Challenges of aging with HIV include a high risk of co-morbidities, a double burden of intersectional stigma related to both aging and HIV, and an accelerated aging process. Previous research has shown that older PLHIV are more likely to be socially isolated. The intersection of HIV-related stigma and ageism is a complex issue requiring further research on the design and feasibility of implementing stigma reduction interventions. There is also an urgent need for research to address critical gaps in our understanding of the impacts of aging on the health of PLHIV and the nature of the accelerated aging process in PLHIV. There is therefore a need to train the next generation of researchers to address these challenges and to design, implement, and scale-up tailored and context-specific interventions for the growing population of older PLHIV in Uganda and similar resource-limited settings. In the past 4 years, we have established a comprehensive research-training program at Makerere University (Mak) with emphasis on strengthening leadership and expertise in Behavioral and Social Sciences Research (BSSR-D43TW011304) to address the evolving challenges in HIV care and prevention in Uganda. We have built on longstanding and productive collaborations between faculty at Mak and the University of California San Francisco (UCSF), to provide a suitable environment for interdisciplinary training in BSSR. We propose to continue the program and focus the next year and a renewal application to address the challenges of HIV and aging. We propose a one-year supplement to spur interest in research on HIV and aging and to obtain preliminary data to inform future long-term research training in this area. Specifically, we aim to: 1) broaden the MakBSSR training program to include research training on HIV and aging, ageism, and intersectional stigma, 2) provide research training and mentorship to masters and postdoctoral fellowship trainees to address the evolving challenges of HIV and aging in Uganda and, 3) prepare a renewal application of the MakBSSR research training program focused on aging with HIV, ageism and intersectional stigma. This supplement will leverage existing resources of the MakBSSR program including collaborations among social, behavioral, and biomedical scientists at Mak, collaborating HIV programs, and partner universities in the USA. During the one-year supplement, we plan to train one master’s degree candidate and two post-doctoral fellowship trainees, all at Mak.