CONDUCT DISORDER IN ADOLESCENT GIRLS--PATHS TO ADULTHOOD

这份科学家发展奖的申请书名为 《青春期女孩的品行障碍：成年之路》我的初选 人们对青春期女孩的行为方式很感兴趣 将精神障碍(CD)引导至成年早期及以后。最近的证据表明 研究表明，a)在青春期女孩中比 以前意识到的，成人的结果通常是 严重的社会和精神障碍，即使没有关联 有明显的犯罪行为。人们对发育轨迹或 与各种结果相关的路径，或哪些基线因素可能 重要的是要让一个女孩为了一个特定的结果而处于危险之中。更少 已知这些女性成年发育的各个阶段。 研究项目1包括对现有数据集的二次分析- -匹兹堡青年研究。这项研究中有1500个男孩的母亲将 根据以下条件被指定为无CD、可能CD或确定CD的诊断 之前收集的有关反社会行为的信息 青春期。自1987年以来，每年都会对这些女性进行跟踪调查 直到现在。他们的心理功能、社会素质 人际关系，育儿技巧，就业和教育历史， 犯罪行为、药物使用和病史将被追踪 这段时间。除了衡量这些女性的结果外， 任何一个时间点，数据都将被用来探索随机模型 描述通向各种结果的道路。 研究项目2是一项对65名患有CD的女孩进行的对照前瞻性研究 以及65名没有CD的女孩(N=130)，他们将根据以下指标进行比较 精神稳定性，神经心理功能，睾丸激素， 雄烯二酮，雌二醇，二氢表雄酮(DHEA)，其硫酸盐 (脱氢表雄酮(-S)和性激素结合球蛋白(SSBG)血浆水平，测量 身体攻击和间接攻击，以及在人际关系中的作用 两性关系。这些参数将在年度评估中进行跟踪 三年，超出了最初的评估。 这些项目结合在一起，跨越了从青春期到 成年早期，提供数据以完善将被检验的假说 在一项针对青春期女孩的大型、一般人群纵向研究中 带CD。国家发改委的最终目标是准备申请 资助这样一个项目。

This application for a Scientist Development Award SDAC) is entitled "Conduct Disorders in Adolescent Girls: Paths To Adulthood." My primary interest is in the behavioral pathways taken by adolescent girls with Conduct Disorder (CD) into early adulthood and beyond. Recent evidence has emerged to suggest that a) in adolescent girls is more common than previously realized, and that the adult outcomes are often characterized by significant social and psychiatric dysfunction, even when not associated with overt criminality. Little is known about the developmental tracks or paths associated with the various outcomes, or what baseline factors may be important in placing a girl at risk for a particular outcome. Even less is known about the stages of adult development in these women. Research Project 1 consists of secondary analyses of an existing data set - - the Pittsburgh Youth Study. The mothers of 1500 boys in the study will be assigned a diagnosis of No CD, Probable CD, or Definite CD, based on information previously collected about antisocial behavior during their adolescence. These women have been followed at yearly intervals from 1987 to the present. Their psychological functioning, quality of social relationships, parenting skills, employment and education histories, criminal behavior, substance use and medical histories will be tracked over this time period. In addition to measuring the outcomes for these women at any one point in time, the data will be used to explore stochastic models to describe the paths taken to various outcomes. Research Project 2 is a controlled, prospective study of 65 girls with CD and 65 girls without CD (N= 130) who will be compared on the basis of psychiatric stability, neuropsychological function, testosterone, androstenedione, and estradiol, dyhydroepiandrosterone (DHEA), its sulfate (DHEA(-S) and sex steroid binding globulin (SSBG) plasma levels, measures of physical and indirect aggression, and functioning in interpersonal relationships. These parameters will be tracked in yearly evaluations for three years, beyond the initial assessment. In combination, these projects span the life cycle from adolescence to early adulthood, providing data to refine hypotheses that will be tested in a large, general population-based longitudinaI study of adolescent girls with CD. The final goal of the SDAC is to prepare an application for funding such a project.