EPIDEMIOLOGY OF ALZHEIMER'S DISEASE IN 3 ETHNIC GROUPS

这项研究将估计老年人痴呆症的患病率 老年痴呆症(SDAT)在65岁及以上的男性和女性中， 使用标准的、可比较的方法。测试仪器也将被 在现场验证，以确定是否出现差异和 非洲人的SDAT负担中存在已确定的风险因素 美国人、古巴裔美国人和非西班牙裔白人。医疗和工作 饮食和心血管系统的病史、人口学和测量 将收集参数以确定其他变量的横截面 与SDAT相关联，并确定 认知正常的三个民族。后续分析将 对检测呈阳性或阴性的参与者的样本也进行检测 特定的筛查认知测试以确定敏感度和 在美国混合文化人群中检测SDAT的特异性。 将首先在选定的人口中确定可能的病例 佛罗里达州戴德县的人口普查区域使用筛查仪器 认知障碍。将转介可能患有痴呆症的已定义病例 去两家记忆障碍诊所中的一家进行标准的一系列测试 诊断SDAT和其他痴呆症。到那时，可能的病例数量将 被用来计算疾病在三个民族中的流行率 组。约4000名参与者将接受检查， 各民族人数均等，男女人数相等。这个 认知正常的评估人群将可用于未来 SDAT危险因素与发病率的纵向研究。

This study will estimate the prevalence of Senile Dementia of the Alzheimer's Type (SDAT) among men and women 65 years of age and older, using standard, comparable methodology. Test instruments will also be validated in the field, to establish whether differences in occurrence and identified risk factors exist in the burden of SDAT among African Americans, Cuban Americans and white non-Hispanics. Medical and work histories, demographics, and measures of diet and cardiovascular system parameters will be collected to identify other variables cross sectionally associated with SDAT and to determine whether differences exist between the three ethnic groups among the cognitively normal. Follow-up analyses will also be done on a sample of participants testing positive or negative for specified screening cognitive tests to establish the sensitivity and specificity for detection of SDAT in a mixed cultural U.S. population. Possible cases will be first identified among populations in selected census tracts in Dade County Florida using screening instruments for cognitive impairment. Defined cases of possible dementia will be referred to one of two Memory Disorder Clinics for a standard battery of tests to diagnose SDAT and other dementias. The number of probable cases will then be used to calculate prevalence of the disease among the three ethnic groups. Approximately four thousand participants will be examined with equal numbers in each ethnic group and equal numbers of men and women. The cognitively normal evaluated population will be available for future longitudinal studies of risk factors and incidence of SDAT.