Dermatoscopy in the Evaluation of Pigmented Lesions

本项目的范围仅限于描述与各种常见的、获得性黑色素细胞痣和罕见遗传性色素性干皮病患者相对应的视觉特征。在临床方案06-C-0060(Thomas J.Hornyak，M.D.，Ph.D.，首席研究员)的主持下，患者被招募到皮肤科诊所进行黑色素细胞痣的研究和组织采集。使用数字皮肤镜设备，用数字发光显微镜对选定的病变进行成像，该设备允许在照明放大下对这些病变进行评估。用这项技术可以观察到与良性或恶性色素病变相关的某些结构。我们收集病变随着时间的推移的图像，并分析它们的变化和新结构的存在，这些结构可以与特定类型或组织病理学上的细胞排列相关联。此外，在与Kenneth Kraemer和John DiGiovanna博士的合作下，我们获得了大约20名色素性干皮病患者的皮肤镜活检图像。这些患者已经在Kraemer博士的专注于色素性干皮病的临床方案的主持下在NIH临床中心就诊。目前，已从这些患者那里获得信息的20多个皮损正在使用标准皮肤镜标准进行分析，以寻找可能允许其临床分类为恶性或良性的特征。此外，有时还会对着色性干皮病患者的家庭成员进行皮肤镜检查，对选定的色素病变进行评估。

The scope of this project is limited to describing visual characteristics corresponding to various types of pigmented lesions in common, acquired melanocytic nevi and in patients with the rare genetic disease xeroderma pigmentosum. Under the auspices of clinical protocol 06-C-0060 (Thomas J. Hornyak, M.D., Ph.D., Principal Investigator), patients are recruited to the Dermatology Clinic for study and tissue acquisition of melanocytic nevi. Selected lesions are imaged with digital epiluminescent microscopy using a device, the digital dermatoscope, that permits evaluation of these lesions under illuminated magnification. Certain structures correlated with benign or malignant pigmented lesions can be observed with this technique. We collect images of lesions over time and analyze them for changes and for the presence of novel structures that can be correlated with specific types or arrangements of cells histopathologically. Also, in collaboration with Drs. Kenneth Kraemer and John Digiovanna, we have obtained digital dermatoscopic images of biopsied pigmented skin lesions on approximately 20 patients with xeroderma pigmentosum. These patients have been seen at the NIH Clinical Center under the auspices of Dr. Kraemer's clinical protocol focused upon xeroderma pigmentosum. Currently the greater than twenty lesions whose information has been obtained from these patients are being analyzed, using standard dermatoscopic criteria, for features that may permit whether they can be classified clinically as malignant or benign. In addition, dermatoscopic evaluation of selected pigmented lesions on family members of those affected with xeroderma pigmentosum is sometimes performed.