Optics

这个新的、重组的核心的目的是提供物理、光学成像和光谱学，以及 为PPG提供数学建模支持。在这样做时，我们期待着新方法和新办法 将与5个单独项目的具体目标密切相关地制定。光学当然是一种 光动力疗法的关键要素，以及光学剂量学从一开始就是核心的主题。新的 对核心的科学强调建立在认识到有重大机会可供开发的基础上 生物医学光学在临床前和临床光动力疗法背景下的进展。因为它有着悠久的传统 将光动力疗法从实验室带到临床，罗斯韦尔公园癌症研究所(RPCI)可能是独一无二的 位于美国，在这一领域取得突破。令人兴奋的机会存在于以下几个方面 级别。例如，PDT治疗的损伤必须是光学可及的，这使得 将光学光谱监测与光动力疗法的交付相结合。光动力疗法中使用的光敏剂 荧光，这使得它们可以通过细胞和体内的荧光成像直接检测到。预付款 在分子成像策略中，成像治疗诱导的基因表达、肿瘤和 正常组织血管系统和宿主细胞对亚细胞分辨率体内治疗的反应。重要 光动力沉积微观影响因素的研究进展 剂量已经导致了新的和非常强大的PDT剂量学数学模型的发展，这是 具有告知和获知正在进行和计划中的临床试验的能力。一项额外的 核心的重要作用是继续为临床前和 临床激光和光纤传输系统是每个项目不可或缺的。《公约》的具体目标 光谱学、分子成像和剂量学建模的核心是：1)继续提供 为临床仪器提供技术和科学支持，该仪器将PDT传递与荧光和 反射光谱；2)开发与ALL密切相关的体内分子成像方法 项目；3)利用微观PDT剂量学的新模型来为设计和解释提供信息 临床试验；4)为临床和临床前提供常规工程和光学支持 PPG的研究努力。

The purpose of this new, reorganized Core is to provide physics, optical imaging and spectroscopy, and mathematical modeling support for the PPG. In so doing, we anticipate that new methods and approaches will be developed in close connection to the specific aims of the 5 individual projects. Optics is of course a critical element of PDT, and optical dosimetry has been a theme of the Core from the beginning. The new scientific emphasis of the Core builds on the realization that there are significant opportunities to exploit advances in biomedical optics within the context of preclinical and clinical PDT. Because of its long tradition of bringing PDT from the laboratory to the clinic, Roswell Park Cancer Institute (RPCI) is perhaps uniquely situated in the United States to make breakthroughs in this area. Exciting opportunities exist on several levels. For example, the lesions treated by PDT are necessarily optically accessible, and this enables integration of optical spectroscopic monitoring with the delivery of PDT. The photosensitizers used in PDT fluoresce, and this renders them directly detectable via fluorescence imaging in cells and in vivo. Advances in molecular imaging strategies have made it possible to image therapy-induced gene expression, tumor and normal tissue vasculature, and host cell responses to treatment in vivo at subcellular resolution. Important advances in understanding the various factors that contribute to the microscopic deposition of photodynamic dose have led to the development of new and very powerful mathematical models of PDT dosimetry, which have the capability of informing and being informed by ongoing and planned clinical trials. An additional important role for the Core is to continue to provide outstanding technical support for the preclinical and clinical laser and fiber delivery systems that are integral to each of the projects. The specific aims of the Optical Spectroscopy, Molecular Imaging, and Dosimetry Modeling Core are: 1) To continue to provide technical and scientific support for the clinical instrument that integrates PDT delivery with fluorescence and reflectance spectroscopy; 2) To develop in vivo molecular imaging methods in close connection to all projects; 3) To utilize a new model of microscopic PDT dosimetry to inform the design and interpretation of clinical trials; and 4) To provide routine engineering and optics support for the clinical and preclinical research efforts of the PPG.