International Symposium on Alcoholic Liver and Pancreatic Disease (ALPD)

描述（由申请人提供）：本R13申请旨在支持将在埃及赫尔格达举行的第四届酒精性肝脏和胰腺疾病（ALPD）和肝硬化国际研讨会。前三届研讨会非常成功，并产生了大量新的合作，导致了该领域的重大进展，我们完全期待这个项目将产生类似的协同效应。本次会议将由埃及卫生部和开罗大学共同主办。主题将包括肝纤维化的机制，肝和胰腺坏死，细胞凋亡和再生，ALPD治疗的新研究，酒精和丙型肝炎病毒导致肝损伤和肝硬化的相互作用。此外，我们将有四场特别讲座，由肝脏和胰腺疾病领域的权威人士提供。目标受众是来自世界各地，特别是中东和非洲的资深和初级研究人员，以及在ALPD领域工作的研究生和博士后研究员。本次会议的总体目标是：1)促进患有酒精性肝脏和胰腺疾病的具有不同遗传和社会背景的不同人口的不同国家之间的国际合作；2)共享各国现有资源，形成合力，形成独特创意；3)鼓励年轻研究者在国际层面上进行互动。通过邀请来自外部学科的演讲者，以及那些利用酒精性肝病新模型的演讲者，我们相信会议将为科学增长和合作创造独特的机会，最终推动该领域的发展。会议结束后，组织者将立即生成书面摘要材料，提交给同行评审期刊，以尽可能广泛地传播会议内容。

DESCRIPTION (provided by applicant): This R13 application seeks support for the Fourth International Symposium on Alcoholic Liver and Pancreatic Disease (ALPD) and Cirrhosis that will be held in Hurghada, Egypt. The prior three Symposia were highly successful and generated a wealth of new collaborations that led to major advances in the field, and we fully anticipate that this program will have a similar, synergizing effect. This meeting will be co-hosted by the Egyptian Ministry of Health and Cairo University. Topics will include mechanisms of liver fibrosis, hepatic and pancreatic necrosis, apoptosis and regeneration, novel research on treatment of ALPD, interactions of alcohol and hepatitis C virus resulting in liver damage and cirrhosis. In addition, we will have four special lectures to be delivered by authorities in the field of liver and pancreatic diseases. The target audience is both established and junior investigators, as well as graduate students and post-doctoral fellows who work in the field of ALPD from all over the world, especially the Middle East and Africa. The overall aims of this meeting are to: 1) promote international collaboration between different countries with different populations of diverse genetic and social background who suffer from alcoholic liver and pancreatic diseases; 2) share the resources available in various countries, thus adding synergy and unique ideas together; and 3) encourage young investigators to interact at an international level. By incorporating speakers from outside disciplines, as well as those utilizing novel models of alcoholic liver disease, we are confident that the meeting will create unique opportunities for scientific growth and collaboration, ultimately advancing the field. Written summary materials will be generated by the organizers immediately after the meeting for submission to a peer reviewed journal to disseminate the contents of the meeting as broadly as possible. PUBLIC HEALTH RELEVANCE: This application seeks support for organizing the fourth international Symposium on Alcoholic Liver and Pancreatic Disease and Cirrhosis, to bring together scientists interested in the damaging effects of alcohol on the liver and pancreas. By providing a forum for experts from many disciplines to discuss the problems related to alcohol abuse and share their latest data, new scientific questions and new directions in the field are likely to emerge. Ultimately, these will lead to scientific breakthroughs that will define new treatments for these serious illnesses caused by alcohol.