Development of a niobuim oxide as a potential coating for dental and orthopedic i

描述（由申请人提供）：全球种植体牙科产品市场预计到2010年将接近35亿美元，尽管全球牙科市场只有9%分配给种植体，但它是增长最快的部分，每年以15%的速度增长。这些预测可能意味着，尽管在全球范围内观察到整体口腔健康的显著改善，但与修复装置相关的重大问题仍然存在，包括多功能性、寿命和性能。更具体地说，与现有种植体材料（牙科或骨科）相关的一些常见故障包括无菌性松动、愈合时间过长以及种植体基质上生物活性涂层的分层。因此，通过连接牙科、生物工程和材料科学领域，我们建议开发一种独特的种植体涂层，它可以与现有的种植体基质协调工作，从而诱导快速的仿生过程，这可能会为公众健康带来重大益处。这项研究的长期目标是开发一种独特的氧化铌涂层，该涂层与植入物基体形成牢固的界面键，同时在体内植入时刺激快速骨整合，用于高负荷应用，如髋关节和牙齿置换。我们假设这种纳米启发的氧化铌涂层由于其在水性电解质中快速氧化而产生的自组装排列而具有令人难以置信的生物活性。所得到的氧化物由微米大小的锥体组成，这些锥体显示出适合磷灰石外延生长的晶体位置，以及有利于细胞附着和生长的拓扑结构。在NIDCR的第一阶段研究计划中，我们提出了以下具体目标：1)在Ti6Al4V衬底上沉积铌金属，然后进行光学和机械验证测量，2)通过划痕测试优化阳极氧化后的铌金属厚度，以及3)验证氧化铌微锥诱导的体内生物活性。

DESCRIPTION (provided by applicant): The worldwide market for implant-based dental products is forecasted to approach $3.5 billion by 2010, and although only 9% of the global dental market is allocated to dental implants, it is the fastest growing segment at a rate of 15% per year. These projections could imply that although significant improvements in overall oral health are observed globally, there remains significant problems associated with prosthodontic devices, including versatility, longevity, and performance. More specifically, some common failures associated with existing implant materials, dental or orthopedic, include aseptic loosening, long healing times, and delamination of bioactive coatings from the implant substrate. Therefore, by bridging the fields of dentistry, bioengineering, and materials science we propose to develop a unique implant coating that could function in harmony with existing implant substrates to induce rapid biomimetic processes may provide a significant public health benefit. The long-term goal of this research endeavor is to develop a unique niobium oxide coating that forms strong interfacial bonds with the implant substrate while stimulating rapid osseointegration when implanted in vivo for high load-bearing applications, such as hip and tooth replacements. We hypothesize this nano-inspired niobium oxide coating exhibits incredible bioactivity by virtue of its self-assembled arrangement created through rapid oxidation in an aqueous electrolyte. The resulting oxide is comprised of micron-sized cones that manifest crystal sites amenable for epitaxial growth of apatite as well as topology that favors cellular attachment and growth. In this Phase 1 research proposal to the NIDCR, we propose to address the following specific aims:1) deposition of niobium metal onto Ti6Al4V substrates followed by optical and mechanical verification measurements, 2) optimizing niobium metal thickness after anodization via scratch tests, and 3) validation of niobium oxide microcone-induced bioactivity in vivo. PUBLIC HEALTH RELEVANCE: The worldwide market for implant-based dental products is forecasted to approach $3.5 billion by 2010, and although only 9% of the global dental market is allocated to dental implants, it is the fastest growing segment at a rate of 15% per year. These projections could imply that although significant improvements in overall oral health are observed globally, there remains significant problems associated with prosthodontic devices, including versatility, longevity, and performance. The long-term goal of this research endeavor is to develop a unique niobium oxide coating that forms strong interfacial bonds with the implant substrate while stimulating rapid osseointegration when implanted in vivo for high load-bearing applications, such as hip and tooth replacements.