Enabling aliphatic biodegradable photoluminescent polymeric biomaterials

描述(由申请人提供)：生物材料是最终生物医学设备或产品的关键部件。一种新的生物材料可能会创造新的研究领域和机会来解决未得到满足的临床问题。我们最近在开发可生物降解的光致发光聚合物(BPLP)方面取得了初步的令人兴奋的发现。与传统的用于照明工业的不可降解的芳香族荧光聚合物不同，BPLP是由柠檬酸、脂肪族二醇和不同的氨基酸等生物相容单体通过非常简单和经济的缩聚反应合成的脂肪族可降解低聚物。BPLP还可以进一步交联成弹性交联聚合物CBPLP。与传统的有机荧光染料、无机量子点和不可降解的荧光聚合物相比，这些聚合物具有优异的细胞相容性、可控的降解性和机械性能，以及在已知的BPLP中荧光发射高达608 nm(峰值波长)的稳定但可调的光致发光性能。这些令人兴奋的发现激励我们进一步开发和理解独特的BPLP，并探索它们在生物标记和成像、组织工程和药物输送方面的潜在巨大机会。在目前的应用中，我们提出了一项高度探索性的研究，以开发和理解独特的生物材料-脂肪族BPLP。我们的长期目标是探索和扩大BPLP在广泛的生物医学应用中的应用，包括生物标记和成像、组织工程和药物输送。本课题的研究目标是合成和表征BPLP生物材料，研究聚合物的生物相容性和血液相容性，展示其在细胞标记/生物成像和组织工程中的潜在应用，并建立一种用于组织工程的非侵入性荧光生物成像方法。与公共健康相关：生物材料是终端生物医学设备或产品的关键组件。一种新的生物材料可能会创造新的研究领域和机会来解决未得到满足的临床问题。在这项提案中，我们将开发能够在广泛的生物医学应用中使用的生物可降解荧光生物材料。我们相信，这项提议的结果将解决组织工程、药物输送和生物成像方面的一些基本问题。新的可生物降解荧光生物材料的发现应该会打开新的研究领域，并对许多科学领域和建立在荧光标记和成像基础上的数十亿美元的行业产生影响。

DESCRIPTION (provided by applicant): Biomaterials are critical components of the end biomedical devices or products. A novel biomaterial may create new fields of studies and opportunities to tackle unmet clinical problems. We have recently achieved preliminary exciting finding on developing biodegradable photoluminescent polymers (BPLPs). Unlike traditional non-degradable aromatic fluorescent polymers used in lighting industry, BPLPs are aliphatic degradable oligomers synthesized by some biocompatible monomers including citric acid, aliphatic diols, and different amino acids via a very simple and cost-effective polycondensation reaction. BPLPs can be further crosslinked into elastomeric crosslinked polymers, CBPLPs. These polymers offer advantages over the traditional fluorescent organic dye, inorganic quantum dots and non-degradable fluorescent polymers in terms of their excellent cytocompatibility, controlled degradability and mechanical properties, and stable but tunable photoluminescent properties with fluorescence emission up to 608 nm (peak wavelength) within the known BPLPs. These exciting findings motivate us to further develop and understand the unique BPLPs and explore their potential huge opportunities in biological labeling and imaging, tissue engineering and drug delivery. In the current application, we are proposing a highly exploratory study to develop and understand the unique biomaterials, aliphatic BPLPs. Our long-term goal is to explore and expand the applications of BPLPs in a broad spectrum of biomedical applications including biological labeling and imaging, tissue engineering and drug delivery. The research objectives of this proposal are to synthesize and characterize the enabling BPLP biomaterials, to study the biocompatibility and hemocompatibility of the polymers, to demonstrate their potential wide applications in cellular labeling/bioimaging and tissue engineering, and to establish a non-invasive fluorescence bioimaging method for tissue engineering. PUBLIC HEALTH RELEVANCE: Biomaterials are critical components of the end biomedical devices or products. A novel biomaterial may create new fields of studies and opportunities to tackle unmet clinical problems. In this proposal, we will develop enabling biodegradable fluorescent biomaterials for uses in a wide range of biomedical applications. We believe that the outcomes of this proposal will address some fundamental issues in tissue engineering, drug delivery and bioimaging. The discovery of the new biodegradable fluorescent biomaterials should open new fields of study and impact on many scientific areas and multi-billion-dollar industries built on fluorescence labeling and imaging.