Low-Cost Device for Digital Retinal Imaging

描述（由申请人提供）：本提案将加快NIBIB RO1 EB002346（“低成本数字视网膜成像设备”）的科学研究节奏，通过通知号（no - od -09-058）根据通知标题：NIH宣布为竞争性修订申请提供恢复法案资金。我们正在改进我们的低成本激光扫描数码相机（LSDC）的新设计，用于无瞳孔扩张的糖尿病视网膜病变筛查，通过在我们的对焦状态上添加电机和传感器，将提供自动对焦的潜力，这将有助于经验不足的操作人员。降低操作人员的成本对于设备的每次使用成本非常重要，从而使筛分能够以更具成本效益的方式完成。为了达到服务不足的人，LSDC不需要瞳孔扩张，但提供高对比度的数字图像。LSDC设计用于小瞳孔和舒适的光照水平，在数据采集过程中产生连续图像，以协助操作员。近红外照明的使用为所有眼睛颜色提供了这种高对比度，因此少数深色眼睛的受试者仍然很容易在舒适的光线水平下成像。提出的新自动对焦功能自动增加了LSDC作为自折射器、白内障检测设备和视网膜地形仪的潜力，以客观的方式检测黄斑水肿。我们将在各种屈光不正和眼睛颜色的受试者、白内障患者和伴有黄斑水肿的视网膜病变的糖尿病患者中测试并优化该设备。我们将与年龄匹配和性别匹配的正常对照受试者进行比较。我们还将把新技术的结果与高端设备的结果进行比较，例如IOL Master，光谱域OCT和波前像差。我们的主要目标是为所有种族的患者提供高对比度的视网膜图像，包括老年患者，以检测糖尿病视网膜病变。增加的功能带来更高的能源效率，因为多个功能可以在一个仪器中完成，从而节省了电力、零件数量、占地面积和病人的椅子时间。该仪器产生的数据也将提供丰富的信息，用于培训学生。

DESCRIPTION (provided by applicant): This proposal will accelerate the tempo of scientific research of NIBIB RO1 EB002346, "Low-Cost Device for Digital Retinal Imaging," by means of Notice Number (NOT-OD-09-058) under the Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. We are enhancing our novel design for a low cost Laser Scanning Digital Camera (LSDC), for use in diabetic retinopathy screening without pupil dilatation, by adding a motor and sensor on our focusing state that will provide the potential for autofocus, which will assist operators with little experience. Reducing the cost of operators is important in the per use cost of the device, allowing screening to be accomplished in a more cost effective manner. To reach the underserved, the LSDC does not require pupil dilation and yet provides a high contrast, digital image. The LSDC is designed to work well with small pupils and comfortable light level, producing continuous images to assist the operator during data acquisition. The use of near Infrared illumination provides this high contrast in all eye colors, so that minority subjects who have dark eyes still readily imaged with comfortable light levels. The proposed new autofocus feature automatically adds the potential for the LSDC serving as an autorefractor, a cataract detection device, and a retinal topographer to detect macular edema in an objective manner. We will test and optimize this device in subjects with a wide range of refractive errors and eye color, patients with cataract, and diabetic patients with retinopathy including macular edema. We will compare performance with that of age-matched and gender-matched normal control subjects. We will also compare the results of the new technology to that of high end devices, such as the IOL Master, spectral domain OCT, and wavefront aberrations. Our main goal is to provide high contrast retinal images in patients of all ethnic groups and including older patients for purposes of detection of diabetic retinopathy. The added functionality leads to greater energy efficiency because several functions can be accomplished in one instrument, saving on power, part count, footprint, and patient chair time. The data produced by this instrument will also provide a wealth of information to be used in the training of students. PUBLIC HEALTH RELEVANCE: We will modify our low cost retinal imaging device, the Laser Scanning Digital Camera, to investigate a low cost method to improve operator focus, measure refraction, investigate eye shape, quantify cataract, and quantify the severity of macular edema. Once developed, increased the functionality requires minimal added cost, providing energy efficiency by combining functions into a single device.