Hybrid Volumetric SPECT/CT Imaging System

描述（由申请人提供）：本共享仪器提案用于将双头SPECT成像系统（Millenium VG，GE healthcare）替换为混合双头容积SPECT/CT成像系统（Philips Medical Systems，Inc.，Rightview VCT），目标是在较大的非啮齿动物中进行放射性核素靶向分子成像。拟议的成像系统将补充我们已建立的小型和大型动物成像设施，并促进我们机构的转化研究。所提出的最先进的SPECT/CT成像系统将支持耶鲁大学医学院的多个当前NIH资助的研究者的需求，这些研究者来自耶鲁大学的医学、诊断放射学、外科学和麻醉学系以及生物医学工程系。用户组从事各种项目，这些项目将利用拟议设备的不同特点。组合的SPECT和X射线CT单元提供功能SPECT图像与解剖CT图像的固有配准，以用于图像量化。CT图像允许校正与SPECT成像相关的衰减和部分体积误差，允许绝对定量放射性示踪剂摄取。该系统的特点将是关键的发展计划，在有针对性的分子成像。拟议的混合体积SPECT/CT成像将成为耶鲁转化动物中心（Y-TRAC）的一个组成部分，该中心正在进行阶段性开发，并将与大型动物饲养和手术设施共同定位，并提供最先进的成像资源用于转化动物研究。该中心将很好地补充我们目前的耶鲁临床研究中心（YCCI），该中心最近由NIH CTSA资助，用于建立临床和转化研究的综合环境。资金将通过YCCI提供，以资助新调查人员的试点项目。 公共卫生相关性：拟议的最先进的SPECT/CT成像系统将支持耶鲁大学医学院的多个当前NIH资助的研究人员的转化研究，这些研究人员来自耶鲁大学的医学、诊断放射学、外科学和麻醉学系以及生物医学工程系。该成像系统将允许实验分子成像剂和生物工程血管的测试和验证。这些类型的尖端技术的成功开发将在未来提供更好的个性化医疗保健。

DESCRIPTION (provided by applicant): This shared instrument proposal is for replacement of a dual-head SPECT Imaging System (Millenium VG, GE healthcare) with a hybrid dual-head volumetric SPECT/CT imaging system (Brightview VCT, Philips Medical Systems, Inc.), with a goal of radionuclide targeted molecular imaging in larger non-rodent animals. The proposed imaging system will complement our established facilities for imaging of both small and large animals and facilitate translational research at our institution. The proposed state- of-the-art SPECT/CT imaging system will support the needs of multiple current NIH funded investigators at Yale University School of Medicine, from the Departments of Medicine, Diagnostic Radiology, Surgery, and Anesthesiology, and the Department of Biomedical Engineering at Yale University. The user group works on a variety of projects, which would utilize different features of the proposed equipment. The combined SPECT and X-ray CT unit provides inherent registration of functional SPECT images with anatomical CT images for the purpose of image quantification. The CT images allow for correction of attenuation and partial volume errors associated with SPECT imaging, permitting absolute quantification of radiotracer uptake. This system feature will be critical for the development of a program in targeted molecular imaging. The proposed hybrid volumetric SPECT/CT imaging will become an integral part of the Yale Translational Animal Center (Y-TRAC), which is under phase development, and will co-locate large animal holding and surgery facilities with state-of-the-art imaging resources for translational animal research. This center will nicely complement our current Yale Center for Clinical Investigation(YCCI), which was recently funded by an NIH CTSA grant for establishing an integrated environment for clinical and translational research. Funds will be available through the YCCI to fund pilot projects from new investigators. PUBLIC HEALTH RELEVANCE: The proposed state-of-the-art SPECT/CT imaging system will support the translational research of multiple current NIH funded investigators at Yale University School of Medicine, from the Departments of Medicine, Diagnostic Radiology, Surgery, and Anesthesiology, and the Department of Biomedical Engineering at Yale University. The imaging system will allow for the testing and validation of experimental molecular imaging agents and bioengineered blood vessels. The successful development of these types of cutting edge technologies will provide for improved and personalized health care in the future.