Time-of-Flight Mass Spectrometer for Synthesis Supporting Biomedical Research

描述（由申请人提供）：生物医学研究的许多方面的进展严重依赖于新的合成化合物和生物材料的发展。质谱是合成研究人员的一个关键工具，本请求的目的是提供必要的质谱仪器，以加强新化合物和生物材料的发现。需要一个现代化的最先进的飞行时间（TOF）质谱仪，并配备适当的附件，用于快速分析各种新的合成化合物。该系统将配备电喷雾（ESI）和大气压化学电离（APCI）组合源，用于引入精确质量测量的内部标准的入口，需要时用于化学分离的快速HPLC系统，适当时用于直接循环注射的计算机控制开关阀，自动进样器和开放获取软件。该仪器将是支持超过8个nih资助项目具体目标的重要组成部分，这些项目将加强对合成过程的理解，为生物医学研究创造新的材料和设备，并开发诊断和治疗药物。拟议的飞行时间质谱仪系统将由加州大学洛杉矶分校分子仪器中心（MIC）支持和管理，这是一个校园范围内的综合设施，旨在提高现有共享的复杂仪器设备对该机构更广泛的研究社区的可访问性。在校园核心设施中使用质谱仪将极大地促进一系列项目的进展，这些项目旨在创造新的分子，为许多人类疾病提供治疗和诊断方法。这项研究将影响一系列人类健康问题，包括各种细菌和病毒疾病、结核病、乳腺癌、激素难治性前列腺癌、心脏病、糖尿病和阿尔茨海默病。公共卫生相关性：要求为整个校园的核心设施提供质谱仪，这将极大地促进旨在创造新分子的各种项目的进展，这些新分子将为许多人类疾病提供治疗和诊断方法。这项研究将影响一系列人类健康问题，包括各种细菌和病毒疾病、结核病、乳腺癌、激素难治性前列腺癌、心脏病、糖尿病和阿尔茨海默病。

DESCRIPTION (provided by applicant): The progress of many aspects of biomedical research is critically dependent on the development of new synthetic compounds and biomaterials. A key tool for synthetic researchers is mass spectrometry and the aim of this request is to provide the necessary mass spectrometry instrumentation to enhance discovery of new compounds and biomaterials. A modern state-of-the-art time-of-flight (TOF) mass spectrometer with appropriate accessories for rapid analysis for a variety of new synthetic compounds is requested. This system will be equipped with a combination electrospray (ESI) and atmospheric pressure chemical ionization (APCI) source, an inlet for introduction of internal standard for exact mass measurements, a rapid HPLC system for chemical separations when needed, a computer-controlled switching valve for direct loop injection when appropriate, an autosampler, and open access software. This instrument will be a vital component to support the specific aims of over 8 NIH-funded projects that enhance the understanding of the synthetic process, create new materials and devices for biomedical research, and develop diagnostic and therapeutic agents. The proposed time-of-flight mass spectrometer system will be supported and administered by the UCLA Molecular Instrumentation Center (MIC), a campus-wide, integrated facility formed to enhance the accessibility of existing shared, sophisticated instrumentation facilities to the broader research community at the institution. The availability of a mass spectrometer in a campus core facility will greatly facilitate the progress of a wide range of projects designed to create new molecules that will produce therapeutics and diagnostic methods for a number of human diseases. The research will impact a range of human health issues, including various bacterial and viral diseases, tuberculosis, breast cancer, hormone refractory prostate cancer, heart disease, diabetes and Alzheimer's disease. PUBLIC HEALTH RELEVANCE: A mass spectrometer is requested for a campus-wide core facility, which will greatly facilitate the progress of a wide range of projects designed to create new molecules that will produce therapeutics and diagnostic methods for a number of human diseases. The research will impact a range of human health issues, including various bacterial and viral diseases, tuberculosis, breast cancer, hormone refractory prostate cancer, heart disease, diabetes and Alzheimer's disease.