Roswell Park Cancer Institute Center Support Grant

描述(申请人提供)：罗斯韦尔公园癌症研究所(RPCI)自1974年被NCI指定为综合癌症中心以来，一直被公认为综合癌症中心，目前正在请求联邦政府在未来五年继续提供支持。RPCI是一家独立的研究、教育和临床癌症护理研究所，占地27英亩，位于布法罗市中心附近，临床和研究空间已扩大到近160万GSF，比上一次审查期间增加了16%。 RPCI为纽约西部约150万人口提供服务，那里的RPCI肿瘤登记每年记录了3400多名新的癌症患者。RPCI与布法罗大学和Hauptman-Woodward结构生物学研究所有着密切的合作，但它是一个完全独立的实体，由Donald Trump博士、CCSG Pi和RPCI总裁/首席执行官组成，只向RPCI董事会负责。 自上次竞争更新以来，RPCI显著增长，表现为：1)招募了100多名新的教职临床医生和研究人员，其中43人是CCSG的新成员；2)NCI资金总额增加了74%，同行评审资金总额增加了44%；3)研究人员发起的干预性临床试验的收益增加了73%，所有干预试验的收益增加了44%；4)增加4个新的共享资源，机构投资超过200万美元；(5)开设一座新的、17.7万GSF的最先进的研究大楼，容纳计划成员实验室和共享资源。随着教职员工的增加，还招聘了三名高级领导人。此外，还为新成立的RPCI癌症健康差异研究办公室招聘了一名主任。作为RPCI科学发展的一部分，在这次更新中增加了一个新的针对疾病的研究计划--前列腺计划，使RPCI六个科学计划包括癌症预防和人口科学、细胞应激和生物物理治疗、遗传学、分子靶标和实验治疗以及肿瘤免疫学和免疫治疗。 凭借强大的领导力和机构承诺，RPCI将继续专注于招聘有才华的研究人员，以进一步扩大针对遗传学、调查成像和癌症健康差异领域的研究努力。

DESCRIPTION (provided by applicant): The Roswell Park Cancer Institute (RPCI) has been continuously recognized as a Comprehensive Cancer Center since the NCI designation of such centers in 1974 and is now requesting continued federal support for the next five years. A free-standing research, education and clinical cancer care Institute, RPCI occupies a 27 acre campus near downtown Buffalo and has expanded to nearly 1.6M gsf of clinical and research space, a 16% increase since the last review period. RPCI serves a population base of ~1.5M in Western New York where the RPCI tumor registry is recording more than 3,400 new cancer patients per year. RPCI has strong collaborations with the University of Buffalo and the Hauptman-Woodward Institute for Structural Biology, but is a fully independent entity with Dr. Donald Trump, CCSG PI and RPCI President/CEO, answering only to the RPCI Board of Directors. Since the last competitive renewal, the RPCI has grown significantly as demonstrated by: 1) the recruitment of over 100 new faculty clinicians and researchers of which 43 are new CCSG members; 2) a 74% increase in total NCI funding and a 44% increase in total peer-reviewed funding; 3) a 73% increase in accrual to investigator-initiated, interventional clinical trials and a 44% increase to accrual in all interventional trials; 4) the addition of 4 new shared resources with an institutional investment of over $2.0 M and (5) the opening of a new, 177,000 gsf, state-of-the-art research building housing Program member laboratories and Shared Resources. With the growth in faculty has also come the recruitment of three Senior Leaders. In addition, a director for the newly created RPCI Office of Cancer Health Disparities Research has also been recruited. As part of the scientific growth within RPCI, a new disease-specific Research Program, the Prostate Program, has been added in this renewal bringing RPCI to a total of six Scientific Programs that also include Cancer Prevention & Population Sciences, Cell Stress & Biophysical Therapies, Genetics, Molecular Targets & Experimental Therapeutics and Tumor Immunology & Immunotherapy. With strong leadership and institutional commitment, RPCI will continue to focus on recruiting talented investigators to further expand research efforts targeting areas in genetics, investigational imaging and cancer health disparities.