Hazardous Waste Risk and Remediation in the Southwest

描述（由申请人提供） 该提案的标题抓住了其本质，“西南地区的危险废物风险和补救”。亚利桑那大学SBRP续期申请建立在以前的补助金的成就。 该方案的主题是通过毒理学和水文地质学研究以及通过开发创新的补救技术，支持制定金属和有机污染物的风险评估程序。 该申请强调了美国西南部（和墨西哥边境）的危险废物问题，因为该环境具有独特的干旱性质。 然而，研究结果并不局限于西南部，因为被检查的主要有毒物质，砷和卤代烃，是无处不在的整个发达国家。 该计划包括10个研究项目-五个生物医学项目和五个环境科学项目。 许多项目都是涉及多个学科的合作项目。生物医学项目正在研究As毒性在靶组织中的机制，影响人群对As诱导毒性敏感性的因素，以及As和TCE对器官发育的影响。环境科学项目正在研究如何对危险废物（As、TCE/四氯乙烯[PCE]）进行最佳表征，以便在干旱的西南环境中进行修复和创新技术，以遏制或降解这些污染物。 这些研究项目由5个核心支持，这些核心管理该计划，将结果翻译给利益相关者，提供研究服务，促进对墨西哥的独特推广工作，并支持研究生培训。 该项目将有助于我们了解毒理学和国内和国际危险废物的补救。

DESCRIPTION (provided by applicant) The title of this proposal captures its essence, 'Hazardous Waste Risk and Remediation in the Southwest'. The University of Arizona SBRP renewal application builds on the achievements of the previous grant. The theme of this Program is to support development of a risk assessment process for metal and organic contaminants through toxicologic and hydrogeologic studies and through development of innovative remediation technologies. The application emphasizes hazardous waste issues in the Southwestern U.S. (and Mexican Border) due to the unique arid nature of this environment. However, the results of the studies are not limited to the Southwest since the main toxicants being examined, As and halogenated hydrocarbons, are ubiquitous throughout developed countries. The Program consists of 10 research projects-five biomedical projects and five environmental sciences projects. Many of the projects are collaborative involving multiple disciplines. The biomedical projects are examining the mechanism of As toxicity in target tissues, factors that affect the susceptibility of populations to As-induced toxicity, and the effects of As and TCE on organ development. The environmental sciences projects are investigating how hazardous wastes (As, TCE/perchloroethylene [PCE]) can be optimally characterized for remediation and innovative techniques for containing or degrading these contaminants in an arid Southwest environment. These research projects are supported by 5 cores that administer the Program, translate the results to the stakeholders, provide research services, promote unique outreach efforts to Mexico, and support graduate student training. This project will contribute to our understanding of toxicology and remediation of hazardous wastes nationally and internationally.