REUSE IN RI: A STATE-BASED APPROACH TO COMPLEX EXPOSURES

描述（由申请人提供） 这个超级基金基础研究和培训计划-RI中的再利用：复杂暴露的基于状态的方法-通过研究和推广解决三个相互关联的主题挑战：1）土地再利用，2）基于状态的方法，以及3）复杂暴露。罗得岛面积小，人口稠密，工业活动历史悠久。学术界、政府领导人和社区成员共同努力解决基础和转化研究问题、管理决策和再利用危险废物场地所固有的沟通复杂性，几乎没有什么障碍。 该研究将5个生物医学项目和3个工程项目集中在跨学科重点领域：纳米技术与金属，分子流行病学与生殖，半挥发性有机物与蒸汽侵入，研究毒物诱导的疾病机制，开发与共同暴露相关的潜在生物标志物，并识别，表征，分离和修复复杂的混合物。这些项目由分析核心化学和生物统计学，分子病理学核心和培训核心支持。研究翻译和社区外展核心促进知识和信息在参与学者，政府领导人和社区成员之间的流动，形成真正的大学-国家-社区伙伴关系。行政核心提供基础设施，以促进沟通，关键的自我评价和资源管理。 该计划为罗得岛州居民提供了一个技术卓越的响应中心，该中心采用以研究为导向的方法来解决在考虑危险废物场地再利用时出现的复杂的科学，工程和社会问题，重点关注以下具体目标： * 提供领导-在环境健康和技术的基础和应用研究，教学和服务方面取得卓越成就。 * 催化研究-增加对健康风险的了解，解决与补救相关的技术挑战。 * 加强连通性-建立跨领域的桥梁，创造新的跨学科培训和教育机会。 * 研究翻译和社区外展-宣传健康危害，指导污染场地的再利用计划，并提高国家机构和社区团体的能力。 行政核心（Boekelheide） 说明（申请人提供） 行政核心（核心A）的主要目标是促进，组织和促进SBRP围绕环境健康，土地再利用和共同暴露问题在罗得岛的跨学科研究活动。布朗大学的SBRP“罗得岛的再利用：一种基于州的复杂暴露方法”于2005年4月开始资助。指导调查人员的要素集中在混合暴露，采取以州为基础的方法进行环境健康研究，技术开发和污染土地再利用，以罗得岛为实验室。在最初的三年资助期间，研究人员已经在布朗和整个罗得岛建立了自己作为智力活动、基础研究和应用科学的创新项目。新成立的中心环境健康和技术（CEHT），由布朗大学公司在2007年春天正式承认，加强了我们SBRP的身份，地位和能力。CEHT提供了一个结构，以扩大研究人员的研究和核心活动，并促进与布朗大学内的其他计划，并与社区和政府机构在罗得岛州的合作。SBRP的具体目标包括： 具体目标1：制定支持和适应跨学科基础和应用研究与培训增长的进程。 具体目标2：维持一个加强团队建设和促进信息传播的沟通结构。 具体目标3：实施机制，将最佳地促进该计划的目标，并确保最佳和负责任地使用现有资源。

DESCRIPTION (provided by applicant) This Superfund Basic Research and Training Program-Reuse in RI: A State-Based Approach to Complex Exposures-tackles through research and outreach three inter-related thematic challenges: 1) land reuse, 2) a state-based approach, and 3) complex exposures. Rhode Island is small, densely populated, and burdened by a long history of industrial activity. There are few barriers to academics, government leaders, and community members working together to address basic and translational research issues, management decisions, and communication complexities inherent to re-using hazardous waste sites. The research clusters 5 Biomedical and 3 Engineering Projects into Interdisciplinary Focus Areas: Nanotechnology & Metals, Molecular Epidemiology & Reproduction, and Semi-Volatile Organics & Vapor Intrusion, that investigate toxicant-induced disease mechanisms and develop potential biomarkers associated with co-exposures, and identify, characterize, separate, and remediate complex mixtures. These projects are supported by an Analytical Core-Chemistry and Biostatistics, a Molecular Pathology Core, and a Training Core. The Research Translation and Community Outreach Cores facilitate the flow of knowledge and information among the participating academics, government leaders, and community members in a true university-state-community partnership. The Administrative Core provides the infrastructure to promote communication, critical self-evaluation, and resource management. This program provides Rhode Islanders with a responsive center of technical excellence that takes a research-oriented approach to resolving the complex scientific, engineering, and societal issues that arise when considering the reuse of hazardous waste sites, by focusing on the following specific objectives: * Provide Leadership - achieve excellence in basic and applied research, teaching, and service in environmental health and technology. * Catalyze Research - increase understanding of health risks and solve technological challenges associated with remediation. * Enhance Connectivity - build bridges across fields and create new interdisciplinary training and educational opportunities. * Research Translation and Community Outreach - communicate health hazards, guide plans for reuse of contaminated sites, and increase the capacity of state agencies and community groups. ADMINISTRATIVE CORE (Boekelheide) Description (provided by applicant) The primary objective of the Administrative Core (Core A) is to promote, organize and facilitate the cross disciplinary research activities of the SBRP around environmental health, land re-use and co-exposure issues in Rhode Island. Brown University's SBRP, "Reuse in Rhode Island: A State-Based Approach to Complex Exposures," began funding in April 2005. The elements that guide the investigators focus on Mixed Exposures, take a State-Based approach to environmental health research, technology development, and contaminated land re-use with Rhode Island as their laboratory. During their initial three years of funding, the investigators have established themselves as an innovative program of intellectual activity and of basic research and applied science at Brown and throughout Rhode Island. The newly established Center for Environmental Health and Technology (CEHT), officially recognized by the Brown University Corporation in spring, 2007, has strengthened the identity, status and capabilities of our SBRP. CEHT provides a structure for expanding the investigators research and core activities, and facilitates collaboration with other programs within Brown University, and with community and government agencies within the State of Rhode Island. The Specific Aims of the SBRP include: Specific Aim 1: Develop processes that support and accommodate the growth of the interdisciplinary basic and applied research and training. Specific Aim 2: Maintain a communication structure that strengthens team building and facilitates the dissemination of information. Specific Aim 3: Implement mechanisms that will optimally promote the program's objectives and ensure the best and responsible use of the available resources.