Computational Anatomy and Multidimensional Modeling

描述（由申请人提供）：这个竞争性更新申请将继续计算解剖学和多维建模资源，将超越当前假定静态形态的脑地图集和地图，并禁止检查时变变化。在相当大的生产力和成功的基础上，我们将继续开发框架和工具，以严格评估大脑结构和功能的动态变化，特别是侧重于发育、衰老和特定疾病的进展等过程。有四个研究领域是至关重要的：1)图像处理和分割，2)变形形态测量和配准，3)混叠，和4)信息学。每一个都相互补充，形成一个综合而全面的研究项目。这种对计算解剖学和多维建模的独特关注与许多其他专注于图像采集的神经成像中心形成鲜明对比。我们的努力包括与一个多元化和资金充足的基础、应用和临床科学家小组合作，研究健康和疾病中的神经科学问题。这些积极和富有成效的合作项目是根据他们与我们的核心研究工作的互利和共生关系以及他们资助项目的具体目标来选择的。我们将继续以强大的软件的形式为其他调查人员提供服务，访问我们的计算机硬件资源以及制作动画和图像渲染。我们通过出版物、电子媒体、小册子和制作描述我们的资源、其软件、专业知识、培训和合作机会的迷你cd来传播有关我们资源的信息。为学生和同事提供现场和远程培训机会，包括实践经验，准备材料，研讨会和交互式电子演示。行政结构和国家认可的咨询委员会帮助我们管理资源的责任。我们对这个资源的计划建立在图像分析、形态测量变异性、大脑映射和可视化的广泛研究历史之上。这一点，加上我们在资源活跃时期的成功，使我们能够完美地继续增长我们的资源。

DESCRIPTION (provided by applicant): This competitive renewal application to continue a Resource for Computational Anatomy and Multidimensional Modeling will go beyond current atlases and maps of brain that assume a static morphology and prohibit the examination of time varying changes. Building upon considerable productivity and success, we will continue to develop the framework and tools to rigorously evaluate dynamic changes in brain structure and function focusing particularly on processes such as development, aging and the progression of specific diseases. There are four areas of research that are of critical importance: 1) Image Processing and Segmentation, 2) Deformation Morphometry and Registration, 3) Aliasing, and 4) Informatics. Each of these compliments the others to form an integrated and comprehensive research program. This unique focus on computational anatomy and multidimensional modeling is in contrast to many other neuroimaging centers where the focus is on image acquisition. Our efforts include numerous collaborations with a diverse and well-funded group of basic, applied and clinical scientists working on neuroscientific problems in health and disease. These active and productive collaborative projects were selected on the basis of their mutually beneficial and symbiotic relationship with our core research efforts and the specific aims of their funded projects. We will continue to provide service to other investigators in the form of robust software, access to our computer hardware resources and production of animations and image renderings. We disseminate information about our Resource by publication, electronic media, a brochure, and the creation of mini-CD's describing our Resource, its software, expertise, training and collaborative opportunities. Training opportunities for students and colleagues are available on site and remotely and include hands-on experiences, prepared material, workshops, and interactive electronic presentations. An administrative structure and nationally recognized advisory board help us manage the responsibilities of the Resource. Our plans for this Resource build upon an extensive history of research in image analysis, morphometric variability, brain mapping and visualization. This, coupled with our successes in the active period of the Resource, positions us perfectly to continue the growth of our Resource.