Therapeutically Applicable Research to Generate Effective Treatments (TARGET)

NCI的治疗应用研究以产生有效治疗(TARGET)倡议的目标是确定儿童癌症的有效治疗目标，以便快速开发新的、更有效的治疗方法。TARGET由癌症基因组学办公室(OCG)和癌症治疗评估计划(CTEP)协调。 对儿童癌症的新治疗方法有着压倒性的需求。在过去几十年里，癌症儿童在健康结果方面取得的早期胜利已经放缓。此外，目前儿童癌症的治疗方法可能有严重的短期和长期副作用，最近的分子靶向治疗进展在很大程度上局限于成人癌症的治疗。TARGET倡议旨在帮助带来靶向癌症治疗的新时代，以应对折磨儿童的癌症。 在追求其目标的过程中，TARGET利用了其他NCI项目的优势，包括儿童肿瘤学小组(COG)、癌症基因组图谱(TCGA)和评估癌症签名的战略伙伴关系(SPECS)。这些合作应该加速发现治疗靶点，并催化将这些发现转化为临床应用，最终目标是减轻儿童癌症的负担。上汽集团获得下一代测序能力，并获得数据协调服务。

The goal of NCI's Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative is to identify valid therapeutic targets in childhood cancers so that new, more effective treatments can be rapidly developed. TARGET is coordinated by the Office of Cancer Genomics (OCG) and the Cancer Therapy Evaluation Program (CTEP). There is an overwhelming need for new treatment approaches to childhood cancers. The early victories in health outcomes of the last several decades for children with cancer have slowed. Furthermore, the current treatments for childhood cancers can have serious short- and long-term side effects, and recent molecularly targeted therapy advances have been largely limited to the treatment of adult cancers. The TARGET Initiative seeks to help bring the new era of targeted cancer therapy to bear on the cancers that afflict children. In pursuing its goals, TARGET leverages the strengths of other NCI programs, including the Children's Oncology Group (COG), The Cancer Genome Atlas (TCGA), and the Strategic Partnership to Evaluate Cancer Signatures (SPECS). These collaborations should expedite the discovery of therapeutic targets and catalyze the translation of these findings for clinical application with the ultimate goal of reducing the burden of childhood cancer. SAIC obtains nextgen sequencing capabilities and procures data coordination services.