BIOINFORMATICS SHARED RESOURCE

莫里斯棉花癌症中心(NCCC)生物信息学共享资源(BISR)作为核心运行 设施自2002年以来。BISR是在NCCC内开发的，作为满足生物信息学的资源 它不仅满足了NCCC的需求，而且已经扩展到为整个达特茅斯研究界提供服务。 生物信息学在现代癌症研究中发挥着中心作用，通过存储、管理、检索、 以及生物医学数据的计算分析。然而，生物信息学的成功应用 需要结合先进的计算基础设施和训练有素的技术人员 计算机编程、数据库和软件工程方面的专业知识。将专业人员结合起来 和中央核心设施的基础设施为癌症研究人员提供访问关键生物信息学的途径 服务和智力支持。集中的生物信息学核心设施的规模经济 支持可为个人调查员带来极大的成本节约和更高效的数据分析 可能没有在自己的实验室中提供计算支持的资源或专业知识。BISR已经 在过去的三年里，随着新的领导层、新的人员、 和新的计算基础设施，以提供最先进的生物信息学支持，包括计算机 编程、数据库设计和开发、数据挖掘、高性能计算和软件 工程学。这一核心与生物统计学、基因组学、分子生物学和 蛋白质组学共享服务作为综合生物学小组的一个组成部分提供协调支持 对于将这些专业知识和工具应用于基因组水平分析的研究人员来说。我们已经成功地 建立了有效的机制，为所有高通量的生物信息学应用提供最新的 来自NCCC社区的数据集，这个核心设施的总体目标是继续为NCCC提供 研究人员为他们的癌症研究提供最先进的技术支持和服务，费率低至 有可能，这样他们就可以继续在任何方向上满足他们的研究目标，他们的假设 而结果可能会领先。

The Morris Cotton Cancer Center (NCCC) Bioinformatics Shared Resource (BISR) has operated as a core facility since 2002. The BISR was developed within the NCCC as a resource to meet the bioinformatics needs of the NCCC but has expanded to provide services to the entire Dartmouth research community. Bioinformatics plays a central role in modern cancer research through the storage, management, retrieval, and computational analysis of biomedical data. However, the successful application of bioinformatics requires a combination of advanced computing infrastructure and a highly trained technical staff with expertise in computer programming, databases, and software engineering. Combining the specialized staff and infrastructure into a central core facility provides the cancer researcher access to critical bioinformatics services and intellectual support. The economy of scale of a centralized core facility for bioinformatics support yields tremendous cost-savings and more efficient data analysis for the individual investigator who may not have the resources or expertise to provide computational support in their own lab. The BISR has been significantly strengthened and expanded over the past three years with new leadership, new personnel, and new computing infrastructure to provide state-of-the-art bioinformatics support, including computer programming, database design and development, data-mining, high-performance computing, and software engineering. This core collaborates very closely with the Biostatistics, Genomics, Molecular Biology, and Proteomics Shared Services as a component of the Integrative Biology Group to provide coordinated support for the investigator applying these expertise and tools for genomic-level analyses. We have successfully established an effective mechanism to provide the latest bioinformatics applications for all high-throughput datasets from the NCCC community, and the overall goal of this core facility is to continue to provide NCCC researchers with state-of-the-art technical support and services for their cancer research, at as low a rate as possible, so that they can continue to meet their research objectives in whatever direction their hypotheses and results may lead.