Postdoctoral Training Program in Genomic Medicine

基因组学技术足够先进，可以测量DNA序列变异和RNA表达 临床样本。然而，将基因组测量整合到医疗保健中的速度正在超过培训 许多人没有能力利用这些信息来改善病人的健康。 因此，培养下一代基因组医学的医生和科学家领袖势在必行。在… 宾夕法尼亚大学，我们提出了一个基因医学博士后培训计划，重点是 转化医学和信息学，由爱德华·罗斯信息学教授杰森·摩尔博士领导， 和宾夕法尼亚大学生物医学信息学研究所所长，以及医学教授凯瑟琳·内桑森 他是艾布拉姆森癌症中心人口科学部的副主任。这是一个挑战 该计划为基因组医学培训奠定了基础，适用于医学博士和博士生 研究员，认识到每个人都可能拥有不同的技能集和经验。它是这样的 必须为所有研究员提供强大的背景框架，以便他们能够发展令人兴奋的和 基因组医学中的相关项目。实习生将参加一个为期两年的项目，包括授课 课程、临床和实验室轮换、互动学习体验和研究培训。我们需要 平衡的课程组合，将涵盖基因组学的最新进展，重点是 疾病过程中的基因组学，包括生物医学信息学和生物统计学在内的定量科学， 科学写作和ELSI问题。32名培训师是根据他们在基因组学方面的专业知识挑选出来的 医学，来自多个科室，随着临床医生的经验进一步扩大 提供基因组医学。学员将在一个研究项目中由一个平衡的团队进行双重指导 (如临床医生和基础科学家)在基因组医学方面有经验。实习生将参加临床 旋转设计的目的是让他们体验从生成大规模并行序列到 从数据到数据分析，再到向患者报告结果。受训人员还将参加互动 活动，包括期刊俱乐部、进行中的研究演示、临床遗传学轮询和 撤退。这种课程作业、体验式临床轮换、参与互动活动、 有指导的研究经验将为我们的医生和科学家在基因组医学领域的职业生涯做好准备。 宾夕法尼亚大学的申请者池异常强大和多样化，我们预计 能够吸引优秀的候选人。我们计划在头两年每年招收两名学员，以及 在后三年中有三次。

Genomics technology is sufficiently advanced to measure DNA sequence variation and RNA expression in clinical samples. However, the integration of genomic measurements into healthcare is outpacing the training of physicians and scientists, and many are ill-equipped to use this information to improve the health of patients. Thus, it is imperative to train the next generation of physician and scientist leaders in Genomic Medicine. At the University of Pennsylvania, we propose a post-doctoral training program in Genomic Medicine, focused on translational medicine and informatics, to be led by Drs. Jason Moore, Edward Rose Professor of Informatics, and Director of the Penn Institute for Biomedical Informatics, and Katherine Nathanson, Professor of Medicine and Genetics, and Associate Director of Population Sciences, Abramson Cancer Center. A challenge for this program is providing a foundation for training in Genomic Medicine, applicable to both MD and PhD trained fellows, recognizing that each may enter the program with different skill sets and experiences. It is thus essential to provide all fellows with a strong background framework so that they can develop exciting and relevant projects in Genomic Medicine. The trainees will enroll in a two year program, including didactic courses, clinical and laboratories rotations, interactive learning experiences and research training. We require a balanced portfolio of courses, which will cover the latest advances in genomics, focused on the role of genomics in disease processes, quantitative sciences, including biomedical informatics and biostatistics, scientific writing and ELSI issues. The 32 trainers have been selected based on their expertise in Genomic Medicine and come from multiple departments, which is further enlarged with clinicians experience in the provision of Genomic Medicine. The trainees will be dually mentored in a research project by a balanced team (e.g. clinician and basic scientist) experienced in Genomic Medicine. Trainees will participate in clinical rotations designed to give them experiences that range from the generation of massively parallel sequence data to data analysis to reporting back the results to patients. Trainees also will participate in interactive activities, which include a journal club, research in progress presentations, clinical genetics rounds and retreats. This combination of coursework, experiential clinical rotations, participation in interactive activities, and mentored research experience will prepare our physicians and scientists for careers in Genomic Medicine. The applicant pool at the University of Pennsylvania is exceptionally strong and diverse, and we anticipate being able to attract outstanding candidates. We plan to enroll two trainees per year for the first two years, and three in the latter three years.