转基因小鼠设施（共享资源）-猫眼课题宝

转基因小鼠设施（共享资源）

批准号：

7944541

负责人：

Arthur D Lander

金额：

$5.07万

依托单位：

UNIVERSITY OF CALIFORNIA-IRVINE

依托单位国家：

美国

项目类别：

财政年份：

2009

资助国家：

美国

项目状态：

已结题

起止时间：

2009-04-06 至 2012-01-31

来源：

https://reporter.nih.gov/project-details/7944541

关键词：

Age Alleles Aneuploidy Animal Model Antibiotic Resistance Applications Grants Back Base Pairing Breeding Cancer Biology Cancer Center Support Grant Cancer Model Cancer Research Project Cell Culture Techniques Cell Line Cell Lineage Cells Characteristics Chimera organism Chromosomes Client Code Complex Consultations Cryopreservation DNA Derivation procedure Development Disease ES Cell Line Electroporation Embryo Embryo Transfer Engineering Equipment Event Fees Female Fertilization in Vitro Fostering Freezing Funding Gene Expression Gene Targeting Genes Genome Genomics Genotype Goals Grant Green Fluorescent Proteins Growth Hand Harvest Head Health Status Hour In Vitro Individual Injection of therapeutic agent Institution Intention Karyotype Karyotype determination procedure Knock-in Mouse Knock-out Knowledge LacZ Genes Letters Life Link Location Malignant Neoplasms Measures Methods Microinjections Mission Molecular Mothers Mouse Strains Mus Mutation Nature Non-Commercial Sources Oocytes Outcome Partner in relationship Pattern Phenotype Plasmids Positioning Attribute Process Proteins Reporter Genes Research Research Personnel Resistance Resource Sharing Resources Role Services Site Southern Blotting Staging Stretching Tail Technology Temperature Time Tissues Transgenes Transgenic Mice Transgenic Mouse Facility University of California Irvine Cancer Center Work base blastocyst cost embryonic stem cell experience homologous recombination human disease in vivo interest mature animal member offspring pathogen pluripotency preimplantation promoter recombinase transmission process

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中文摘要

翻译

加州大学欧文分校转基因小鼠设施的使命是促进转基因小鼠的使用在假设驱动的研究，提供服务，使，育种，基因分型，进口，保存小鼠品系。我们的主要目标是以尽可能低的成本提供这些服务，产生的产量和成果与其他学术机构的类似设施相比毫不逊色。我们在协助开发体内哺乳动物癌症模型方面处于有利地位，提供了对理解癌症的分子基础至关重要的小鼠品系。

英文摘要

The mission of the Transgenic Mouse Facility at UC-lrvine is to facilitate the use of genetically modified mice in hypothesis-driven research by providing services for making, breeding, genotyping, importing, and preserving mouse strains. Our primary goal is to offer these services at the lowest possible cost while producing yields and outcomes that compare favorably with similar facilities at other academic institutions. We are in a strong position to assist in the development of in vivo mammalian models of cancer and to provide strains of mice that are critical to understanding the molecular basis of cancer.

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