Optimising combinations of calcium channel inhibitors for treatment of secondary degeneration after neurotrauma

中枢神经系统的创伤性损伤会因从最初的撞击点向外扩散而变得更加严重。过多的钙进入细胞是扩散损伤的关键因素，但单一钙通道抑制剂的治疗一直令人失望。我们将使用钙通道抑制剂的组合来阻断多个钙通道，并确保优化的组合在临床相关的神经创伤模型中有效。

Traumatic injury to the central nervous system is made worse by damage that spreads away from the initial point of impact. Excess calcium entering cells is a key contributor to spreading damage but treatment with single calcium channel inhibitors has been disappointing. We will use combinations of calcium channel inhibitors to block multiple calcium channels and ensure the optimised combination is effective in clinically relevant models of neurotrauma.