Melanoma Prevention: Using the Sun

描述（由申请人提供）：本申请-黑色素瘤预防：使用太阳-旨在转发和发展博士贝里克的职业目标。这些是三重的。 (1)正在进行的目标：进行研究，将导致理解和消除发病率和死亡率从黑色素瘤。在耶鲁大学接受免疫学、暴露评估和流行病学培训后，贝里克博士开始了一项系统的研究议程，重点是一种明显可预防的疾病-黑色素瘤的癌症预防谱。目前的研究集中在基因-环境相互作用和黑色素瘤生存的重要因素。 (2)作为K 05支持的结果：培养年轻的博士前，博士后和教师成为生产力科学家。贝里克博士的研究项目为初级研究人员的新研究提供了一个很好的平台。新举措的例子包括探索阳光和维生素D与维生素D受体及其途径的相互作用，免疫因素和激素对黑色素瘤病因和生存的影响。贝里克博士在促进新一代癌症预防科学家的学术发展方面的领导才能，这些科学家经过培训，可以调查遗传学和暴露与癌症风险的关系。该奖项将提供时间，以支持扩大这一指导作用，释放了贝里克博士的一部分行政责任。贝里克博士是理想的定位，承担一个高级指导作用在这个时候，因为在这个奖项的时候，所有，但她的主要研究支持这一建议将已完成或移交给初级研究人员，留下40%的新的时间和精力可用于新的研究和指导。 (3)作为K 05支持的结果：对贝里克博士的研究技能和方向的持续增长和完善的贡献：通过了解其病因和制定适当的和区域特定的干预措施来影响新墨西哥州的癌症健康差异。在新墨西哥州开展以人群为基础的病例对照研究的新举措，将提供对该州主要种族人群（西班牙裔、非西班牙裔白人和美洲原住民）癌症发病率、生存率和死亡率的新差异和模式的重要理解。贝里克博士在基于人群的调查和分子流行病学方面的广泛经验将促进这些新的研究。 这些目标将通过玛丽安·贝里克博士开发的强大指导计划、通过利用现有的博士和博士后项目以及开发新的博士和博士后职位来改善指导和培训基础设施，以及通过更彻底地检查现有的和新的数据来实现。通过校外资助收集的黑色素瘤病因、进展和病因学数据。 这些目标是通过贝里克博士24年来指导年轻教师和调查太阳暴露在皮肤恶性黑色素瘤的发展和进展中的作用而制定的。贝里克博士的目标-了解和消除黑色素瘤的发病率和死亡率-反映了国家癌症优先事项，以消除痛苦和死亡的癌症到2015年。NCI将开展和支持基础、临床和人口研究，以更全面地了解癌症的遗传、表观遗传、环境、行为和社会文化决定因素，以及癌症耐药性、易感性、启动、消退、进展和复发的生物学机制。国家癌症研究所明确指出，预防必须以在人口和实验室工作的综合人口科学小组所积累的知识为基础。 公共卫生相关性：这个K 05应用程序的目标是：（1）培养年轻的博士前，博士后和教师成为生产力的科学家，（2）有助于博士的研究技能和方向的持续增长和完善：通过了解病因和制定适当的人群特异性干预措施，影响新墨西哥州的癌症健康差异，和（3）进行研究，以了解和消除黑色素瘤的发病率和死亡率。这些结果应该会导致更多的教师接受癌症预防培训，特别是少数民族教师，以及更多基于证据的建议，以更好地预防癌症，特别是快速增加的肿瘤，皮肤黑色素瘤，并使黑色素瘤患者的生存预测更好。

DESCRIPTION (provided by applicant): This application - Melanoma Prevention: Using the Sun - is intended to forward and develop Dr. Berwick's career goals. These are three-fold. (1) Ongoing goal: To conduct studies that will lead to understanding and eliminating morbidity and mortality from melanoma. After obtaining training in immunology, exposure assessment, and epidemiology at Yale University, Dr. Berwick began a systematic research agenda concentrating on the spectrum of cancer prevention for an eminently preventable disease - melanoma. Current studies focus on gene-environment interaction and factors important for survival with melanoma. (2) As a Result of K05 Support: To develop young pre-doctoral, post-doctoral and faculty into productive scientists. Dr. Berwick's research projects provide an excellent platform for new research by junior investigators. Examples of novel initiatives include exploration of interaction effects of sunlight and Vitamin D with the vitamin D receptor and its pathway, immunological factors and hormonal influences on both etiology and survival with melanoma. Her long history of successful mentoring clearly demonstrates Dr. Berwick's leadership skills in fostering the academic development of a new generation of cancer prevention scientists trained to investigate genetics and exposure in relationship to cancer risk. This award would provide time to support the expansion of this mentoring role by freeing up a portion of Dr. Berwick's administrative responsibilities. Dr. Berwick is ideally positioned to assume a senior mentoring role at this time since at the time of this award, all but her primary research supporting this proposal will have been completed or handed over to junior investigators, leaving 40% new time and effort available for new research and mentoring. (3) As a Result of K05 Support: Contribution to the continued growth and refinement of Dr. Berwick's Research Skills and Directions: To impact cancer health disparities in New Mexico by understanding their etiology and developing appropriate and regional-specific interventions. New initiatives to develop population-based case-control studies in New Mexico will provide important understandings of the novel disparities and patterns of cancer incidence, survival and mortality that are present among the state's major ethnic populations: Hispanics, non-Hispanic whites and Native Americans. Dr. Berwick's wide experience in population-based investigations and molecular epidemiology will facilitate these new studies. These goals will be realized through a strong mentoring program developed by Dr. Marianne Berwick, by improving the mentoring and training infrastructure through leveraging existing doctoral and post-doctoral programs and developing new doctoral and post-doctoral positions, and by more thoroughly examining extant and new data in melanoma etiology, progression and etiology which are collected through extramural funding. These goals have been developed through Dr. Berwick's 24 years of mentoring young faculty and investigating the role of solar exposure in the development and progression of cutaneous malignant melanoma. Dr. Berwick's goals - to understand and eliminate morbidity and mortality from melanoma - reflect national cancer priorities to eliminate suffering and death from cancer by 2015. NCI "will conduct and support basic, clinical and population research to gain a more complete understanding of the genetic, epigenetic, environmental, behavioral and socio-cultural determinants of cancer and the biological mechanisms underlying cancer resistance, susceptibility, initiation, regression, progression and recurrence. The NCI clearly states that prevention must be based on knowledge developed by integrative population science teams working in the population and in the laboratory. PUBLIC HEALTH RELEVANCE: The objectives of this K05 Application are: (1) To develop young pre-doctoral, post-doctoral and faculty into productive scientists, (2) To contribute to the continued growth and refinement of Dr. Berwick's research skills and directions: To impact cancer health disparities in New Mexico by understanding their etiology and developing appropriate and population-specific interventions, and (3) To conduct studies that will lead to understanding and eliminating morbidity and mortality from melanoma. The results should lead to more faculty trained in cancer prevention, particularly minority faculty, and more evidence-based recommendations for better cancer prevention, particularly for the rapidly increasing tumor, cutaneous melanoma, and enable better survival prediction for melanoma patients.