The Reward Circuit: Emerging, Reemerging, and Forgotten Brain Areas

描述（由申请人提供）：在2010年5月将有一个会议，包括一系列的研讨会，重点是“奖励电路：新兴，重新出现，和被遗忘的领域”。位于北卡罗来纳州赖茨维尔海滩的贝壳岛海滨套房。主要研究者是Dr. Suzanne N。哈伯，罗切斯特大学，和共同组织者是：博士克里斯泰尔鲍纳兹，安东尼格雷斯，杰奎琳麦金蒂，塞莱斯特纳皮耶，帕特里西奥奥唐纳，琳达波里诺，菲利普温和斯科特扎姆。为了促进积极的非正式讨论，会议将包括一系列的讲习班，而且规模较小。为了筹备会议，我们选择了四个研讨会主题。设立了四个重点小组，以提出供讲习班讨论的问题和议题。焦点小组由7-14名科学家组成，包括临床和基础科学家，以及初级和高级科学家。这些小组还将准备一份介绍性摘要，在每次研讨会开始时就一个特定的主题进行介绍。每次研讨会之后，将为所有与会者举行总结会议。讲习班将是一个公开论坛，由一名主持人主持，并由一名抄写员编写书面摘要。研讨会将致力于所有与会者的积极参与，解决跨越特定专业领域的新问题和方向。这种独特的形式在我们以前的会议上非常成功，鼓励自由交流意见。一个具体的重点是招募年轻科学家到该领域。因此，每个讲习班将至少有一名青年科学家担任领导角色（抄写员或主讲人）。此外，还将为青年科学家举办一次专门讨论与职业发展有关的问题的特别讲习班。 公共卫生相关性：奖赏回路是涉及动机障碍的病理学的核心，包括成瘾。某些关键结构，如前额叶皮层，纹状体和中脑多巴胺细胞在这一电路是最相关的精神疾病。然而，为了提高我们对这些病理的理解，还必须关注该系统中的其他结构，而不是通常研究的结构。本次会议的主题是“奖励回路：新兴，重新出现和被遗忘的区域”，这是特别及时的，因为它汇集了关于与皮质纹状体奖励系统相关的各种大脑区域的新的和令人兴奋的信息。了解这些关键的联系提供了新的治疗干预不同的精神疾病，包括成瘾强迫症，抑郁症和精神分裂症的潜在机会。

DESCRIPTION (provided by applicant): In May 2010 there will be a meeting consisting of a series of workshops focusing on "The Reward circuit: emerging, re-emerging, and forgotten areas". Shell Island Oceanfront Suites in Wrightsville Beach, North Carolina. The Principal Investigator is Dr. Suzanne N. Haber, University of Rochester, and the co- organizers are: Drs. Christelle Baunez, Anthony Grace, Jacqueline McGinty, Celeste Napier, Patricio O'Donnell, Linda Porrino, Philip Winn and Scott Zahm. To stimulate active, informal discussion, the meeting consists of a series of workshops and will be relatively small. In preparation for the meeting, we have chosen four workshop topics. Four focus groups have been created to develop the questions and issues for discussion in the workshops. The focus groups are comprised of a cross section of 7-14 scientists to include clinical and basic scientists, and a mixture of junior and senior scientists. These groups will also prepare an introductory summary that begins each workshop on a specific topic. Following each workshop there will be summary session for all of the participants. The workshops will be an open forum, led by a facilitator, with a written summary by a scribe. Workshops will be devoted to active participation from all attendees, addressing new questions and directions that cut across the specific areas of expertise. This unique format, which has been very successful at our previous meetings, encourages free exchange of ideas. A specific emphasis is on recruiting young scientists to the field. Therefore each workshop will engage at least one young scientist in a leadership role (scribe or presenter). Furthermore, there will be a special workshop for junior scientists devoted to questions and issues related to career development. PUBLIC HEALTH RELEVANCE: The reward circuit is central to pathologies involving motivational disorders, including addiction. Certain key structures, such as the prefrontal cortex, striatum and midbrain dopamine cells within this circuitry are the most associated with psychiatric diseases. However, to improve our understanding of these pathologies, it is essential to also focus on other structures within this system, not as commonly studied. The topic of this meeting, "The Reward circuit: emerging, re-emerging, and forgotten areas", is particularly timely as it brings together new, and exciting information on a variety of brain regions that are connected to the cortico-striatal reward system. Understanding these critical links provides potential opportunities for new therapeutic interventions for different psychiatric disorders including addiction OCD, depression and schizophrenia.