Third Genome Dynamics in the Neurosciences Conference

描述(由申请人提供)：对遗传毒性应激的反应是神经系统发育的先决条件。各种DNA修复或DNA损伤反应因子的突变可能会导致以明显的神经病理为特征的人类疾病。在许多这些综合征中，神经部分是这种疾病最有害的方面之一。尽管基因组完整性在神经系统中很重要，但明显缺乏一系列有重点的会议来探索DNA损伤反应在神经系统中的作用。尽管人们清楚地认为DNA修复和DNA损伤信号是神经系统疾病的关键因素，但在科学会议上，关于DNA修复和DNA损伤信号的讨论主要集中在致癌和免疫系统发育上，而关于DNA交易对神经系统的影响的研究令人惊讶地稀少。因此，通常没有一个发展良好的论坛来分享想法或促进学生、研究员和领域领导人之间的互动，因为他们对DNA交易感兴趣，因为它们具体与大脑有关。一个集DNA修复、基因组稳定性和神经系统动态平衡于一体的会议的必要性已经通过一个国际“神经系统中的基因组动力学”会议系列的开始而得到解决。在这项应用中，我们建议召开一次会议，整合DNA损伤信号和修复的基本过程以及神经和神经退行性疾病的临床方面。该计划旨在将对DNA损伤信号具有主要兴趣的领先科学家与那些在特定相关神经退行性疾病领域工作的科学家聚集在一起，作为整合这些领域的手段。预计这将有助于深入了解大脑中基因组维持的正常过程如何有助于预防广泛的疾病。神经系统在临床干预方面提出了特别的挑战，因为神经病理经常出现在神经系统发育过程中。

DESCRIPTION (provided by applicant): The response to genotoxic stress is a prerequisite for development of the nervous system. Mutations in a variety of DNA repair or DNA damage-response factors can lead to human diseases that are characterized by pronounced neuropathology. In many of these syndromes the neurological component is amongst the most deleterious aspects of the disease. Despite the importance of genomic integrity in the nervous system, there is a striking lack of a focused series of meetings that explore the roles for the DNA damage response in the nervous system. Although clearly recognized as key factors in neurological disease, discussions of DNA repair and DNA damage signaling at scientific meetings have been heavily weighted towards carcinogenesis and immune system development, and research on the impact of DNA transaction in the nervous system has been surprisingly sparse. Thus, there has typically been no well-developed forum for sharing of ideas or fostering interactions among students, fellows and field leaders with interests in DNA transactions as they specifically relate to the brain. The need for a conference integrating DNA repair, genome stability and nervous system homeostasis has been addressed by the commencement of an international "Genome Dynamics in the Nervous System" conference series. In this application, we propose a meeting that integrates basic processes of DNA damage signaling and repair and clinical aspects of neurological and neurodegenerative disease. The program is designed to bring together leading scientists with primary interests in DNA damage signaling together with those working in specific related neurodegenerative disease areas as means for integrating these fields. It is anticipated that this will generate insights into how normal processes of genome maintenance in the brain contribute to the prevention of a wide range of diseases. The nervous system poses a particular challenge in terms of clinical intervention, as the neuropathology often arises during nervous system development.