Origins of Renal Physiology

描述（由申请人提供）：沙漠山岛生物实验室寻求NIDDK R13支持第四届年度全国肾脏研究员和住院医师课程，肾脏生理学的起源，2011年9月3日至10日，在沙漠山岛生物实验室（MDIBL），在巴尔港，缅因州。拟议的课程提供肾脏研究员，居民谁将进入肾脏病学，和初级教师，与实践研究培训的基本概念的稳态，并暴露他们的经典实验，形成肾脏生理学和肾脏病学的基础。提出了六个课程模块：肾小球滤过，近端小管功能，厚升支cotransporters，盐分泌和平衡，集合管钠转运/ ENaC，和水稳态。2011年将增加一个遗传学强化单元。六个模块中的每一个都在三个连续的两天轮换中运行（周一至周二，周三至周四和周五至周六），每个轮换的第一天涉及密集的实验工作，第二天涉及分析和向整个会议组展示工作。每个受训人员将在三次轮调期间完成六个计划单元中的三个。肾脏生理学的起源在全国肾脏短期课程中是完全独特的。该课程为参与者提供研究工具，使他们更深入地了解生理稳态的概念，这在正常的临床培训计划中很难实现。该课程对肾脏研究员开放，自2010年以来，也对进入肾脏病学的住院医师开放。研究员和居民都受益于与领导课程模块的肾生理学高级研究人员的密切互动。特别是住院医生，他们可以与来自不同项目的研究员合作，分享他们对肾脏研究和肾脏病学的见解。该过程在MDIBL网站（http：www.mdibl.org）上以及在J. Am.肾脏病学学会（Zeidel等人，J.J. 19：649-50，2008）。所要求的资金将用于支付受训人员的生活费、研究用品和旅费;因此，受训人员承担的学费将大大减少。 公共卫生相关性：“肾脏生理学的起源”课程与生物医学研究和人类健康的进步高度相关。课程参与者是30名肾脏研究员和住院医师，他们将专门从事肾脏病学。这一数字约占美国肾脏研究员年度“班级”的10%，使该课程对全国研究员的培训产生重大影响。课程教师包括临床肾病学家和研究人员。学员进行实验，以阐明肾功能，包括肾小球滤过，近端小管，厚升支，和集合管运输，水稳态，转运蛋白的细胞运输，以及转运蛋白的结构-功能，如水通道蛋白，尿素载体，ENaC和Na/K/2Cl协同转运蛋白。一个新的遗传学模块将展示人类肾脏疾病中的基因突变。

DESCRIPTION (provided by applicant): The Mount Desert Island Biological Laboratory seeks NIDDK R13 support for the fourth annual national course for renal fellows and medical residents, Origins of Renal Physiology, September 3-10, 2011, at the Mount Desert Island Biological Laboratory (MDIBL), in Bar Harbor, Maine. The proposed course provides renal fellows, residents who will enter nephrology, and junior faculty, with hands-on research training in fundamental concepts of homeostasis and exposes them to the classical experiments that form the foundation of renal physiology and nephrology. Six course modules are proposed: glomerular filtration, proximal tubule function, thick ascending limb cotransporters, salt secretion and balance, collecting duct sodium transport / ENaC, and water homeostasis. An enrichment module in genetics will be added in 2011. Each of the six modules runs in three consecutive two-day rotations (Monday-Tuesday, Wednesday-Thursday, and Friday-Saturday), with the first day of each rotation involving intensive experimental work, and the second day involving analysis and presentation of the work to the entire conference group. Each trainee will complete three of the six planned modules during the three rotations. Origins of Renal Physiology is entirely unique among national renal short courses. The course provides participants with research tools that give them a deeper understanding of concepts of physiological homeostasis which is difficult to attain during normal clinical training schedules. The course is open to both renal fellows and, since 2010, medical residents entering nephrology. Fellows and residents alike benefit from close interactions with senior investigators in renal physiology who lead the course modules. Residents, in particular, benefit by working with fellows from different programs and sharing their insights into renal research and nephrology. The course is described on the MDIBL website (http://www.mdibl.org), and in a recent editorial in J. Am. Soc. of Nephrology (Zeidel et al., JASN 19: 649-50, 2008). Requested funds will cover trainee subsistence, research supplies, and travel; therefore, tuition costs carried by the trainee will be significantly reduced. PUBLIC HEALTH RELEVANCE: The course "Origins of Renal Physiology" is highly relevant to biomedical research and the advancement of human health. Course participants are 30 renal fellows and medical residents who will specialize in nephrology. This number represents about 10% of the annual "class" of renal fellows in the United States, permitting the course to have a significant impact on the training of fellows nationally. Course faculty include clinical nephrologists and investigators. The trainees perform experiments to elucidate kidney function including glomerular filtration, proximal tubule, thick ascending limb, and collecting duct transport, water homeostasis, cellular trafficking of transporter proteins, and the structure-function of transporter proteins such as aquaporins, urea carriers, ENaC and the Na/K/2Cl cotransporter. A new genetics module will demonstrate genetic mutations indicated in human kidney diseases.