2011 Eukaryotic mRNA Processing Conference

描述(申请人提供)：拟召开的“真核基因加工”会议将召集科学家研究基因加工、运输、RNA干扰、信息学和翻转等各个方面。最近在这些领域取得了重大进展，拟议的会议将是一个及时的活动，可以讨论最新的未公布结果和交流意见，从而促进这一快速发展领域的新发展。拟议的2011年会议将于8月举行，是每隔一年在冷泉港实验室举行的会议的第八次会议。最近的一次会议于2009年8月举行，吸引了来自世界各地的335名科学家，他们正在利用遗传学、生化、分子和细胞生物学方法，积极研究真核细胞中信使RNA成熟的各个方面。与前几次会议一样，主要重点将放在信使核糖核酸成熟过程中的核事件，特别是信使核糖核酸剪接和聚腺苷酸化，但现在将扩大范围，既包括信使核糖核酸的历史对其最终生物命运的影响，也包括新兴的RNA干扰和微型核糖核酸功能领域，以及信息学和全基因组方法在RNA加工分析中的应用。会议形式将包括八次全体会议和两次海报会议。对于2011年的会议，我们将把每一次全体会议细分为两个部分(用咖啡休息时间隔开)，集中讨论相关但不同的议题。这一细分使我们能够专门寻找更广泛的领域代表，并招募更多样化的教职员工担任会议主席。所有发言者将一如既往地根据提交的摘要选出，这将鼓励初级科学家积极参与。我们将特别鼓励领导这些项目的学生和博士后研究员展示未发表的作品，这一直是冷泉港会议的标志和独特优势。 与公共健康相关：在从酵母到人类的高等生物的基因中，DNA序列中编码的信息被称为内含子的非编码区打断。基因的RNA拷贝必须被读出、剪切，然后再拼接在一起，以去除内含子，并产生含有正确信息的连续“信息”，以产生蛋白质。在许多情况下，信息可以被切割并以不同的组合重新组合在一起，从而产生具有不同功能的蛋白质。这意味着细胞中不同蛋白质的数量可能远远超过不同基因的数量。当产生有缺陷的蛋白质时，RNA剪接中的错误会导致严重的问题，这有时是由于遗传缺陷或疾病造成的。进行这种基因拼接的分子机制非常复杂，必须在细胞内受到严格调控。许多科学家正在研究这种信使RNA加工是如何发生和控制的，这得益于RNA剪接机制在酵母和人类之间高度保守的事实。这次会议将这些科学家聚集在一起讨论他们的最新成果。会议成功的一个关键是，大多数口头报告是由研究生、博士后研究员和初级教员根据科学价值选择的，确保会议展示往往尚未发表的最新发展。参与者来自世界各地的学术中心、研究机构和工业中心，展示和讨论他们的发现。重要的是，此应用程序请求为可能无法出席会议的初级科学家提供支持，以积极参与会议。

DESCRIPTION (provided by applicant): The proposed conference on "Eukaryotic mRNA Processing" will convene scientists studying various aspects of mRNA processing, transport, RNA interference, informatics and turn-over. Major advances have recently been made in these areas, and the proposed conference will be a timely event for discussing the latest unpublished results and exchanging ideas, thereby fostering new developments in this rapidly moving field. The proposed 2011 conference will be held in August and is the eighth meeting of a conference that is held every other year at Cold Spring Harbor Laboratory. The most recent meeting was held in August 2009 and attracted 335 scientists internationally, who are actively investigating various aspects of messenger RNA maturation in eukaryotic cells, using genetic, biochemical, molecular, and cell biological approaches. As in the previous meetings, a major focus will be on nuclear events in mRNA maturation, particularly mRNA splicing and polyadenylation, but the scope will now be expanded to encompass both the impact of the history of an mRNA on its ultimate biological fate, the emerging fields of RNA interference and microRNA function as well as the application of informatics and genome-wide approaches to the analysis of RNA processing. The meeting format will consist of eight plenary sessions and two poster sessions. For the 2011 meeting we will subdivide each plenary session into two parts (separated by a coffee break) that focus on related but separate topics. This subdivision allows us to specifically seek out a broader representation of fields and to recruit a more diverse set of faculty as session chairs. As always, all speakers will be selected on the basis of the submitted abstracts, which will encourage active participation by junior scientists. We will particularly encourage presentation of unpublished work by the students and postdoctoral fellows who are leading these projects, as has traditionally been a hallmark and a unique strength of the Cold Spring Harbor meetings. PUBLIC HEALTH RELEVANCE: In genes of higher organisms from yeast to man, the information encoded in the DNA sequence is interrupted by non-coding regions called introns. An RNA copy of the gene has to be read off, cut and then spliced back together to remove the introns and produce a continuous "message" with the correct information to produce a protein. In many cases, the message can be cut and put back together in different combinations giving rise to proteins with different functions. This means that the number of different proteins in a cell can be much greater than the number of different genes. Mistakes in the splicing of the RNA cause serious problems as defective proteins are produced, and this sometimes happens as a consequence of genetic defects or disease. The molecular machinery that carries out this gene splicing is very complicated and has to be tightly regulated in the cell. Many scientists are studying how this messenger RNA processing occurs and is controlled, helped by the fact that the RNA splicing machinery is highly conserved between yeast and humans. This conference brings these scientists together to discuss their latest results. A key to the success of the conference is that the majority of oral presentations are given by graduate students, postdoctoral fellows and junior faculty chosen on the basis of scientific merit, ensuring that the conference showcases the latest developments which are often yet to be published. Participants come from academic centers, research institutes and industrial centers around the world to present and discuss their findings. Importantly, this application requests support for junior scientists who might not otherwise be able to attend to actively participate in the meeting.